OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 [6.8] years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity determined by exercise testing, and dietary habits quantified by the Food Frequency Questionnaire and 4-Day Food Diary to assess adherence to the Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets were obtained to assess direct effects with neurocognition. Potential indirect associations of high-sensitivity C-reactive protein and the Framingham Stroke Risk Profile also were examined. RESULTS: Greater aerobic capacity (β = 0.24) and daily physical activity (β = 0.15) were associated with better executive functioning/processing speed and verbal memory (βs = 0.24; 0.16). Adherence to the DASH diet was associated with better verbal memory (β = 0.17). Greater high-sensitivity C-reactive protein (βs = -0.14; -0.21) and Framingham Stroke Risk Profile (β = -0.18; -0.18) were associated with poorer executive functioning/processing speed and verbal memory. Greater stroke risk partially mediated the association of aerobic capacity with executive functioning/processing speed, and verbal memory and greater inflammation partially mediated the association of physical activity and aerobic fitness, with verbal memory. CONCLUSIONS: Higher levels of physical activity, aerobic fitness, and adherence to the DASH diet are associated with better neurocognitive performance in adults with CIND. These findings suggest that the adoption of healthy lifestyle habits could reduce the risk of neurocognitive decline in vulnerable older adults. CLINICAL TRIAL REGISTRATION: NCT01573546.
OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 [6.8] years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity determined by exercise testing, and dietary habits quantified by the Food Frequency Questionnaire and 4-Day Food Diary to assess adherence to the Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets were obtained to assess direct effects with neurocognition. Potential indirect associations of high-sensitivity C-reactive protein and the Framingham Stroke Risk Profile also were examined. RESULTS: Greater aerobic capacity (β = 0.24) and daily physical activity (β = 0.15) were associated with better executive functioning/processing speed and verbal memory (βs = 0.24; 0.16). Adherence to the DASH diet was associated with better verbal memory (β = 0.17). Greater high-sensitivity C-reactive protein (βs = -0.14; -0.21) and Framingham Stroke Risk Profile (β = -0.18; -0.18) were associated with poorer executive functioning/processing speed and verbal memory. Greater stroke risk partially mediated the association of aerobic capacity with executive functioning/processing speed, and verbal memory and greater inflammation partially mediated the association of physical activity and aerobic fitness, with verbal memory. CONCLUSIONS: Higher levels of physical activity, aerobic fitness, and adherence to the DASH diet are associated with better neurocognitive performance in adults with CIND. These findings suggest that the adoption of healthy lifestyle habits could reduce the risk of neurocognitive decline in vulnerable older adults. CLINICAL TRIAL REGISTRATION: NCT01573546.
Authors: A F Kramer; S Hahn; N J Cohen; M T Banich; E McAuley; C R Harrison; J Chason; E Vakil; L Bardell; R A Boileau; A Colcombe Journal: Nature Date: 1999-07-29 Impact factor: 49.962
Authors: Patrick J Smith; James A Blumenthal; Benson M Hoffman; Harris Cooper; Timothy A Strauman; Kathleen Welsh-Bohmer; Jeffrey N Browndyke; Andrew Sherwood Journal: Psychosom Med Date: 2010-03-11 Impact factor: 4.312
Authors: James A Blumenthal; Patrick J Smith; Kathleen Welsh-Bohmer; Michael A Babyak; Jeffrey Browndyke; Pao-Hwa Lin; P Murali Doraiswamy; James Burke; William Kraus; Alan Hinderliter; Andrew Sherwood Journal: Contemp Clin Trials Date: 2012-09-19 Impact factor: 2.226
Authors: Teresa T Fung; Kathryn M Rexrode; Christos S Mantzoros; JoAnn E Manson; Walter C Willett; Frank B Hu Journal: Circulation Date: 2009-02-16 Impact factor: 29.690
Authors: Michael T Heneka; Monica J Carson; Joseph El Khoury; Gary E Landreth; Frederic Brosseron; Douglas L Feinstein; Andreas H Jacobs; Tony Wyss-Coray; Javier Vitorica; Richard M Ransohoff; Karl Herrup; Sally A Frautschy; Bente Finsen; Guy C Brown; Alexei Verkhratsky; Koji Yamanaka; Jari Koistinaho; Eicke Latz; Annett Halle; Gabor C Petzold; Terrence Town; Dave Morgan; Mari L Shinohara; V Hugh Perry; Clive Holmes; Nicolas G Bazan; David J Brooks; Stéphane Hunot; Bertrand Joseph; Nikolaus Deigendesch; Olga Garaschuk; Erik Boddeke; Charles A Dinarello; John C Breitner; Greg M Cole; Douglas T Golenbock; Markus P Kummer Journal: Lancet Neurol Date: 2015-04 Impact factor: 44.182
Authors: Christopher J Dondzila; Ann M Swartz; Nora E Miller; Elizabeth K Lenz; Scott J Strath Journal: Int J Behav Nutr Phys Act Date: 2012-12-11 Impact factor: 6.457
Authors: Isabelle Pelcher; Christian Puzo; Yorghos Tripodis; Hugo J Aparicio; Eric G Steinberg; Alyssa Phelps; Brett Martin; Joseph N Palmisano; Elizabeth Vassey; Cutter Lindbergh; Ann C McKee; Thor D Stein; Ronald J Killiany; Rhoda Au; Neil W Kowall; Robert A Stern; Jesse Mez; Michael L Alosco Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Annelien C van den Brink; Elske M Brouwer-Brolsma; Agnes A M Berendsen; Ondine van de Rest Journal: Adv Nutr Date: 2019-11-01 Impact factor: 8.701
Authors: Lotte G M Cremers; Wyke Huizinga; Wiro J Niessen; Gabriel P Krestin; Dirk H J Poot; M Arfan Ikram; Jyrki Lötjönen; Stefan Klein; Meike W Vernooij Journal: Front Aging Neurosci Date: 2020-01-23 Impact factor: 5.750
Authors: Alice Hahn; Young Ju Kim; Hee Jin Kim; Hyemin Jang; Hanna Cho; Seong Hye Choi; Byeong C Kim; Kyung Won Park; Duk L Na; Juhee Chin; Sang Won Seo Journal: Sci Rep Date: 2020-08-12 Impact factor: 4.379
Authors: Mahwesh Saleem; Nathan Herrmann; Adam Dinoff; Graham Mazereeuw; Paul I Oh; Benjamin I Goldstein; Alex Kiss; Prathiba Shammi; Krista L Lanctôt Journal: Psychosom Med Date: 2019 Feb/Mar Impact factor: 4.312