Literature DB >> 26702308

Implementation of a genetic logic circuit: bio-register.

Chun-Liang Lin1, Ting-Yu Kuo1, Yang-Yi Chen1.   

Abstract

We introduce an idea of synthesizing a class of genetic registers based on the existing sequential biological circuits, which are composed of fundamental biological gates. In the renowned literature, biological gates and genetic oscillator have been unveiled and experimentally realized in recent years. These biological circuits have formed a basis for realizing a primitive biocomputer. In the traditional computer architecture, there is an intermediate load-store section, i.e. a register, which serves as a part of the digital processor. With which, the processor can load data from a larger memory into it and proceed to conduct necessary arithmetic or logic operations. Then, manipulated data are stored back to the memory by instruction via the register. We propose here a class of bio-registers for the biocomputer. Four types of register structures are presented. In silicon experiments illustrate results of the proposed design.

Entities:  

Keywords:  Bio-computer; Bio-register; Genetic logic gate; Synthetic biology

Year:  2015        PMID: 26702308      PMCID: PMC4688412          DOI: 10.1007/s11693-015-9186-6

Source DB:  PubMed          Journal:  Syst Synth Biol        ISSN: 1872-5325


  18 in total

1.  Construction of a genetic toggle switch in Escherichia coli.

Authors:  T S Gardner; C R Cantor; J J Collins
Journal:  Nature       Date:  2000-01-20       Impact factor: 49.962

2.  A synthetic oscillatory network of transcriptional regulators.

Authors:  M B Elowitz; S Leibler
Journal:  Nature       Date:  2000-01-20       Impact factor: 49.962

3.  On schemes of combinatorial transcription logic.

Authors:  Nicolas E Buchler; Ulrich Gerland; Terence Hwa
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-17       Impact factor: 11.205

4.  Synthesis of Genetic Clock with Combinational Biologic Circuits.

Authors:  Po-Kuei Chen; Chun-Liang Lin
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2015 Sep-Oct       Impact factor: 3.710

5.  A Novel Synthesizing Genetic Logic Circuit: Frequency Multiplier.

Authors:  Chia-Hua Chuang; Chun-Liang Lin
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2014 Jul-Aug       Impact factor: 3.710

6.  Multi-input RNAi-based logic circuit for identification of specific cancer cells.

Authors:  Zhen Xie; Liliana Wroblewska; Laura Prochazka; Ron Weiss; Yaakov Benenson
Journal:  Science       Date:  2011-09-02       Impact factor: 47.728

7.  Amplifying genetic logic gates.

Authors:  Jerome Bonnet; Peter Yin; Monica E Ortiz; Pakpoom Subsoontorn; Drew Endy
Journal:  Science       Date:  2013-03-28       Impact factor: 47.728

8.  Design of synthetic biological logic circuits based on evolutionary algorithm.

Authors:  Chia-Hua Chuang; Chun-Liang Lin; Yen-Chang Chang; Tanagorn Jennawasin; Po-Kuei Chen
Journal:  IET Syst Biol       Date:  2013-08-01       Impact factor: 1.615

9.  Automatic design of digital synthetic gene circuits.

Authors:  Mario A Marchisio; Jörg Stelling
Journal:  PLoS Comput Biol       Date:  2011-02-17       Impact factor: 4.475

10.  Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology.

Authors:  Baojun Wang; Richard I Kitney; Nicolas Joly; Martin Buck
Journal:  Nat Commun       Date:  2011-10-18       Impact factor: 14.919

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  3 in total

1.  Synthesis of control unit for future biocomputer.

Authors:  Chun-Liang Lin; Ting-Yu Kuo; Wei-Xian Li
Journal:  J Biol Eng       Date:  2018-08-14       Impact factor: 4.355

2.  Toward theoretical synthesis of biocomputer.

Authors:  Ting-Yu Kuo; Chun-Liang Lin; Natdanai Charoenkit; Yang-Yi Chen; Chakkrit Preuksakarn
Journal:  IET Syst Biol       Date:  2017-02       Impact factor: 1.615

3.  Design of dynamic genetic memory.

Authors:  Yu-Jia Hu; Chun-Liang Lin; Wei-Xian Li
Journal:  IET Syst Biol       Date:  2017-12       Impact factor: 1.615

  3 in total

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