Anthony J Smith1, Henry F Duncan2, Anibal Diogenes3, Stephane Simon4, Paul R Cooper5. 1. School of Dentistry, University of Birmingham, Birmingham, United Kingdom. Electronic address: a.j.smith@bham.ac.uk. 2. Division of Restorative Dentistry and Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland. 3. Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas. 4. Department of Oral Biology and Endodontics, School of Dentistry, University of Paris Diderot, Paris, France. 5. School of Dentistry, University of Birmingham, Birmingham, United Kingdom.
Abstract
INTRODUCTION: The development of regenerative endodontic therapies offers exciting opportunities for future improvements in treatment outcomes. METHODS: Advances in our understanding of regenerative events at the molecular and cellular levels are helping to underpin development of these therapies, although the various strategies differ in the translational challenges they pose. The identification of a variety of bioactive molecules, including growth factors, cytokines, chemokines, and matrix molecules, sequestered within dentin and dental pulp provides the opportunity to present key signaling molecules promoting reparative and regenerative events after injury. RESULTS AND CONCLUSIONS: The protection of the biological activity of these molecules by mineral in dentin before their release allows a continuing supply of these molecules, while avoiding the short half-life and the non-human origin of exogenous molecules. The ready release of these bioactive molecules by the various tissue preparation agents, medicaments, and materials commonly used in endodontics highlights the opportunities for translational regenerative strategies exploiting these molecules with little change to existing clinical practice.
INTRODUCTION: The development of regenerative endodontic therapies offers exciting opportunities for future improvements in treatment outcomes. METHODS: Advances in our understanding of regenerative events at the molecular and cellular levels are helping to underpin development of these therapies, although the various strategies differ in the translational challenges they pose. The identification of a variety of bioactive molecules, including growth factors, cytokines, chemokines, and matrix molecules, sequestered within dentin and dental pulp provides the opportunity to present key signaling molecules promoting reparative and regenerative events after injury. RESULTS AND CONCLUSIONS: The protection of the biological activity of these molecules by mineral in dentin before their release allows a continuing supply of these molecules, while avoiding the short half-life and the non-human origin of exogenous molecules. The ready release of these bioactive molecules by the various tissue preparation agents, medicaments, and materials commonly used in endodontics highlights the opportunities for translational regenerative strategies exploiting these molecules with little change to existing clinical practice.
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