| Literature DB >> 28886764 |
Marco C Bottino1, Divya Pankajakshan2, Jacques E Nör3.
Abstract
No current therapy promotes root canal disinfection and regeneration of the pulp-dentin complex in cases of pulp necrosis. Antibiotic pastes used to eradicate canal infection negatively affect stem cell survival. Three-dimensional easy-to-fit antibiotic-eluting nanofibers, combined with injectable scaffolds, enriched or not with stem cells and/or growth factors, may increase the likelihood of achieving predictable dental pulp regeneration. Periodontitis is an aggressive disease that impairs the integrity of tooth-supporting structures and may lead to tooth loss. The latest advances in membrane biomodification to endow needed functionalities and technologies to engineer patient-specific membranes/constructs to amplify periodontal regeneration are presented.Entities:
Keywords: 3D printing; Biomaterials; Dental pulp; Guided tissue regeneration; Periodontitis; Pulpitis; Regenerative endodontics; Scaffolds
Mesh:
Year: 2017 PMID: 28886764 PMCID: PMC5657339 DOI: 10.1016/j.cden.2017.06.009
Source DB: PubMed Journal: Dent Clin North Am ISSN: 0011-8532