Literature DB >> 2669628

SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams.

L Gutmann1, B Ferré, F W Goldstein, N Rizk, E Pinto-Schuster, J F Acar, E Collatz.   

Abstract

SHV-5 (pI 8.2), a novel broad-spectrum beta-lactamase encoded by a ca. 150-kilobase plasmid, was found in Klebsiella pneumoniae 160. SHV-5 beta-lactamase caused decreased susceptibility to most penicillins, cephalosporins, and monobactams, except imipenem and compounds which have a C6 or C7 alpha-methoxy substituent. beta-Lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) inhibited its activity and showed a synergistic effect when associated with different hydrolyzable beta-lactam compounds. Hybridization studies suggested that this enzyme may be related to, or derived from, the SHV enzyme. Increased MICs of cephamycins and temocillin associated with a decreased synergistic effect of the inhibitors on K. pneumoniae 160 might be linked to a decrease in two outer membrane proteins.

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Year:  1989        PMID： 2669628      PMCID： PMC284261          DOI： 10.1128/AAC.33.6.951

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.

Authors:  L Gutmann; M D Kitzis; D Billot-Klein; F Goldstein; G Tran Van Nhieu; T Lu; J Carlet; E Collatz; R Williamson
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

2.  Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.

Authors:  V Jarlier; M H Nicolas; G Fournier; A Philippon
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

3.  Novel plasmid-mediated beta-lactamase in clinical isolates of Klebsiella pneumoniae more resistant to ceftazidime than to other broad-spectrum cephalosporins.

Authors:  A Petit; D L Sirot; C M Chanal; J L Sirot; R Labia; G Gerbaud; R A Cluzel
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

4.  Plasmid-mediated gentamicin resistance not associated with kanamycin resistance in Enterobacteriaceae.

Authors:  J L Witchitz
Journal:  J Antibiot (Tokyo)       Date:  1972-10       Impact factor: 2.649

5.  Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors.

Authors:  M D Kitzis; D Billot-Klein; F W Goldstein; R Williamson; G Tran Van Nhieu; J Carlet; J F Acar; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191

6.  Single amino acid substitution between SHV-1 beta-lactamase and cefotaxime-hydrolyzing SHV-2 enzyme.

Authors:  M Barthélémy; J Péduzzi; H Ben Yaghlane; R Labia
Journal:  FEBS Lett       Date:  1988-04-11       Impact factor: 4.124

7.  Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.

Authors:  D Sirot; J Sirot; R Labia; A Morand; P Courvalin; A Darfeuille-Michaud; R Perroux; R Cluzel
Journal:  J Antimicrob Chemother       Date:  1987-09       Impact factor: 5.790

8.  Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.

Authors:  A Bauernfeind; G Hörl
Journal:  Infection       Date:  1987 Jul-Aug       Impact factor: 3.553

9.  Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes.

Authors:  W Sougakoff; S Goussard; G Gerbaud; P Courvalin
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

10.  The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.

Authors:  B Joris; J M Ghuysen; G Dive; A Renard; O Dideberg; P Charlier; J M Frère; J A Kelly; J C Boyington; P C Moews
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857
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  45 in total

1.  TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.

Authors:  J Kamile Rasheed; Gregory J Anderson; Anne Marie Queenan; James W Biddle; Antonio Oliver; George A Jacoby; Karen Bush; Fred C Tenover
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

2.  Epidemiology of extended-spectrum beta-lactamases in Sofia, Bulgaria.

Authors:  G A Jacoby; R Vacheva-Dobrevsky
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-05-29       Impact factor: 3.267

3.  Cloning of SHV-2, OHIO-1, and OXA-6 beta-lactamases and cloning and sequencing of SHV-1 beta-lactamase.

Authors:  J Mercier; R C Levesque
Journal:  Antimicrob Agents Chemother       Date:  1990-08       Impact factor: 5.191

4.  Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.

Authors:  G Arlet; M J Sanson-le Pors; M Rouveau; G Fournier; O Marie; B Schlemmer; A Philippon
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-11       Impact factor: 3.267

5.  Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.

Authors:  D Billot-Klein; L Gutmann; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

6.  Discrimination of extended-spectrum beta-lactamases by a novel nitrocefin competition assay.

Authors:  G A Papanicolaou; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1990-11       Impact factor: 5.191

7.  A new plasmidic cefotaximase from patients infected with Salmonella typhimurium.

Authors:  A Bauernfeind; J M Casellas; M Goldberg; M Holley; R Jungwirth; P Mangold; T Röhnisch; S Schweighart; R Wilhelm
Journal:  Infection       Date:  1992 May-Jun       Impact factor: 3.553

8.  Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae.

Authors:  Nuno Mendonça; Vera Manageiro; Richard Bonnet; Manuela Caniça
Journal:  Antimicrob Agents Chemother       Date:  2008-03-03       Impact factor: 5.191

9.  Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene.

Authors:  David S Hammond; Tegan Harris; Jan Bell; John Turnidge; Philip M Giffard
Journal:  Antimicrob Agents Chemother       Date:  2007-11-12       Impact factor: 5.191

10.  Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases.

Authors:  D J Payne; R Cramp; D J Winstanley; D J Knowles
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191
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