| Literature DB >> 2088203 |
D Billot-Klein1, L Gutmann, E Collatz.
Abstract
The nucleotide sequence of the SHV-5 beta-lactamase gene, subcloned from a plasmid of Klebsiella pneumoniae, was determined. The amino acid changes thought to be responsible for the extended substrate profile of SHV-5 are Gly----Ser234 and Glu----Lys235. SHV-5 is identical to SHV-4, except for Leu----Arg201, which accounts for the difference in apparent pI of the two enzymes.Entities:
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Year: 1990 PMID: 2088203 PMCID: PMC172080 DOI: 10.1128/AAC.34.12.2439
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191