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Literature DB >> 26694936

Biomaterials and emerging anticancer therapeutics: engineering the microenvironment.

Abstract

The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models using 3D matrices recapitulate key elements of the tumour microenvironment and have revealed new aspects of cancer biology. Cancer vaccines based on some of the same biomaterials have, in parallel, allowed for the engineering of durable prophylactic and therapeutic anticancer activity in preclinical studies, and some of these vaccines have moved to clinical trials. The impact of biomaterials engineering on cancer treatment is expected to further increase in importance in the years to come.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Biocompatible Materials

Year: 2016 PMID： 26694936 PMCID： PMC4790726 DOI： 10.1038/nrc.2015.3

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

181 in total

1. Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors.

Authors: Theodora Fifis; Anita Gamvrellis; Blessing Crimeen-Irwin; Geoffrey A Pietersz; Jie Li; Patricia L Mottram; Ian F C McKenzie; Magdalena Plebanski
Journal: J Immunol Date: 2004-09-01 Impact factor: 5.422

Review 2. The three main stumbling blocks for anticancer T cells.

Authors: Lukas Baitsch; Silvia A Fuertes-Marraco; Amandine Legat; Christiane Meyer; Daniel E Speiser
Journal: Trends Immunol Date: 2012-03-23 Impact factor: 16.687

3. Microvascular permeability of normal and neoplastic tissues.

Authors: L E Gerlowski; R K Jain
Journal: Microvasc Res Date: 1986-05 Impact factor: 3.514

Review 4. "In vitro" 3D models of tumor-immune system interaction.

Authors: Christian Hirt; Adam Papadimitropoulos; Valentina Mele; Manuele G Muraro; Chantal Mengus; Giandomenica Iezzi; Luigi Terracciano; Ivan Martin; Giulio C Spagnoli
Journal: Adv Drug Deliv Rev Date: 2014-05-09 Impact factor: 15.470

5. A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation.

Authors: Virginie Dangles-Marie; Sophie Richon; Mohamed El-Behi; Hamid Echchakir; Guillaume Dorothée; Jérôme Thiery; Pierre Validire; Isabelle Vergnon; Jeanne Menez; Moncef Ladjimi; Salem Chouaib; Dominique Bellet; Fathia Mami-Chouaib
Journal: Cancer Res Date: 2003-07-01 Impact factor: 12.701

6. Rapid 3D Extrusion of Synthetic Tumor Microenvironments.

Authors: Joshua M Grolman; Douglas Zhang; Andrew M Smith; Jeffrey S Moore; Kristopher A Kilian
Journal: Adv Mater Date: 2015-08-18 Impact factor: 30.849

7. Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity.

Authors: Samar Hamdy; Ommoleila Molavi; Zengshuan Ma; Azita Haddadi; Aws Alshamsan; Zahra Gobti; Sara Elhasi; John Samuel; Afsaneh Lavasanifar
Journal: Vaccine Date: 2008-08-03 Impact factor: 3.641

Review 8. The tumor microenvironment and its role in promoting tumor growth.

Authors: T L Whiteside
Journal: Oncogene Date: 2008-10-06 Impact factor: 9.867

9. Why certain dyes are useful for localizing the sentinel lymph node.

Authors: Chris Tsopelas; Richard Sutton
Journal: J Nucl Med Date: 2002-10 Impact factor: 10.057

10. 3D porous chitosan-alginate scaffolds: a new matrix for studying prostate cancer cell-lymphocyte interactions in vitro.

Authors: Stephen J Florczyk; Gang Liu; Forrest M Kievit; Allison M Lewis; Jennifer D Wu; Miqin Zhang
Journal: Adv Healthc Mater Date: 2012-07-06 Impact factor: 9.933

102 in total

Biomaterials and emerging anticancer therapeutics: engineering the microenvironment.

1. Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors.

Review 2. The three main stumbling blocks for anticancer T cells.

3. Microvascular permeability of normal and neoplastic tissues.

Review 4. "In vitro" 3D models of tumor-immune system interaction.

5. A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation.

6. Rapid 3D Extrusion of Synthetic Tumor Microenvironments.

7. Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity.

Review 8. The tumor microenvironment and its role in promoting tumor growth.

9. Why certain dyes are useful for localizing the sentinel lymph node.

10. 3D porous chitosan-alginate scaffolds: a new matrix for studying prostate cancer cell-lymphocyte interactions in vitro.

1. Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells.

Review 2. Advances in Biomaterials for Drug Delivery.

Review 3. Manufacturing Cell Therapies Using Engineered Biomaterials.

Review 4. Delivery technologies for cancer immunotherapy.

5. Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth.

Review 6. Biomaterials for vaccine-based cancer immunotherapy.

Review 7. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.

8. Local delivery of checkpoints antibodies.

9. Biomechanical forces in tissue engineered tumor models.

Review 10. Studying Adipose Tissue in the Breast Tumor Microenvironment In Vitro: Progress and Opportunities.