Literature DB >> 26667849

DNA repair, genome stability and cancer: a historical perspective.

Penny A Jeggo1, Laurence H Pearl1, Antony M Carr1.   

Abstract

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.

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Year:  2015        PMID： 26667849     DOI： 10.1038/nrc.2015.4

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  99 in total

1.  Mutation selection and the natural history of cancer.

Authors:  J Cairns
Journal:  Nature       Date:  1975-05-15       Impact factor: 49.962

2.  Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression.

Authors:  Asa Karlsson; Debabrita Deb-Basu; Athena Cherry; Stephanie Turner; James Ford; Dean W Felsher
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-08       Impact factor: 11.205

3.  Genetic mechanisms of tumor suppression by the human p53 gene.

Authors:  P L Chen; Y M Chen; R Bookstein; W H Lee
Journal:  Science       Date:  1990-12-14       Impact factor: 47.728

4.  A combined bacterial and liver test system for detection and classification of carcinogens as mutagens.

Authors:  B N Ames
Journal:  Genetics       Date:  1974-09       Impact factor: 4.562

5.  Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors:  M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal:  Cell       Date:  1997-03-07       Impact factor: 41.582

6.  The Werner syndrome protein is a DNA helicase.

Authors:  M D Gray; J C Shen; A S Kamath-Loeb; A Blank; B L Sopher; G M Martin; J Oshima; L A Loeb
Journal:  Nat Genet       Date:  1997-09       Impact factor: 38.330

7.  [The first description of an occupational cancer in 1777 (scrotal cancer, cancer of chimney sweeps)].

Authors:  P Pott
Journal:  Bull Soc Liban Hist Med       Date:  1993

8.  Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

Authors:  Iñigo Martincorena; Amit Roshan; Moritz Gerstung; Peter Ellis; Peter Van Loo; Stuart McLaren; David C Wedge; Anthony Fullam; Ludmil B Alexandrov; Jose M Tubio; Lucy Stebbings; Andrew Menzies; Sara Widaa; Michael R Stratton; Philip H Jones; Peter J Campbell
Journal:  Science       Date:  2015-05-22       Impact factor: 47.728

Review 9.  Therapeutic opportunities within the DNA damage response.

Authors:  Laurence H Pearl; Amanda C Schierz; Simon E Ward; Bissan Al-Lazikani; Frances M G Pearl
Journal:  Nat Rev Cancer       Date:  2015-03       Impact factor: 60.716

Review 10.  Mechanisms of resistance to therapies targeting BRCA-mutant cancers.

Authors:  Christopher J Lord; Alan Ashworth
Journal:  Nat Med       Date:  2013-10-07       Impact factor: 53.440
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  232 in total

1.  PertInInt: An Integrative, Analytical Approach to Rapidly Uncover Cancer Driver Genes with Perturbed Interactions and Functionalities.

Authors:  Shilpa Nadimpalli Kobren; Bernard Chazelle; Mona Singh
Journal:  Cell Syst       Date:  2020-07-14       Impact factor: 10.304

Review 2.  DNA Damage and Repair Biomarkers of Immunotherapy Response.

Authors:  Kent W Mouw; Michael S Goldberg; Panagiotis A Konstantinopoulos; Alan D D'Andrea
Journal:  Cancer Discov       Date:  2017-06-19       Impact factor: 39.397

Review 3.  Genomic evolution of cancer models: perils and opportunities.

Authors:  Uri Ben-David; Rameen Beroukhim; Todd R Golub
Journal:  Nat Rev Cancer       Date:  2019-02       Impact factor: 60.716

4.  Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.

Authors:  Jiuping Ji; Yiping Zhang; Christophe E Redon; William C Reinhold; Alice P Chen; Laura K Fogli; Susan L Holbeck; Ralph E Parchment; Melinda Hollingshead; Joseph E Tomaszewski; Quentin Dudon; Yves Pommier; James H Doroshow; William M Bonner
Journal:  PLoS One       Date:  2017-02-03       Impact factor: 3.240

Review 5.  Preserving genome integrity and function: the DNA damage response and histone modifications.

Authors:  Jae Jin Kim; Seo Yun Lee; Kyle M Miller
Journal:  Crit Rev Biochem Mol Biol       Date:  2019-06-04       Impact factor: 8.250

6.  Repair and translesion synthesis of O 6-alkylguanine DNA lesions in human cells.

Authors:  Hua Du; Pengcheng Wang; Lin Li; Yinsheng Wang
Journal:  J Biol Chem       Date:  2019-06-05       Impact factor: 5.157

7.  DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability.

Authors:  Zhiguo Li; Chen Shao; Yifan Kong; Colin Carlock; Nihal Ahmad; Xiaoqi Liu
Journal:  Mol Cell Biol       Date:  2017-04-14       Impact factor: 4.272

8.  Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis.

Authors:  G Chen; B Zhang; H Xu; Y Sun; Y Shi; Y Luo; H Jia; F Wang
Journal:  Oncogene       Date:  2017-09-04       Impact factor: 9.867

Review 9.  Clinically Applicable Inhibitors Impacting Genome Stability.

Authors:  Anu Prakash; Juan F Garcia-Moreno; James A L Brown; Emer Bourke
Journal:  Molecules       Date:  2018-05-13       Impact factor: 4.411

Review 10.  DNA repair defects and implications for immunotherapy.

Authors:  Katherine M Bever; Dung T Le
Journal:  J Clin Invest       Date:  2018-10-01       Impact factor: 14.808
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