| Literature DB >> 26658965 |
Liang Zhou1, Kun Sun1,2, Yu Zhao1,3, Suyang Zhang1,2, Xuecong Wang4, Yuying Li1,2, Leina Lu1, Xiaona Chen1, Fengyuan Chen1,2, Xichen Bao5, Xihua Zhu5, Lijun Wang1, Ling-Yin Tang3, Miguel A Esteban5, Chi-Chiu Wang3, Ralf Jauch4, Hao Sun1,2, Huating Wang1,6.
Abstract
Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of Linc-YY1 from the promoter of the transcription factor (TF) Yin Yang 1 (YY1) gene. We demonstrate that Linc-YY1 is dynamically regulated during myogenesis in vitro and in vivo. Gain or loss of function of Linc-YY1 in C2C12 myoblasts or muscle satellite cells alters myogenic differentiation and in injured muscles has an impact on the course of regeneration. Linc-YY1 interacts with YY1 through its middle domain, to evict YY1/Polycomb repressive complex (PRC2) from target promoters, thus activating the gene expression in trans. In addition, Linc-YY1 also regulates PRC2-independent function of YY1. Finally, we identify a human Linc-YY1 orthologue with conserved function and show that many human and mouse TF genes are associated with lincRNAs that may modulate their activity. Altogether, we show that Linc-YY1 regulates skeletal myogenesis and uncover a previously unappreciated mechanism of gene regulation by lincRNA.Entities:
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Year: 2015 PMID： 26658965 DOI： 10.1038/ncomms10026
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919