Jorien Seggers1, Martina Pontesilli2, Anita C J Ravelli3, Rebecca C Painter4, Mijna Hadders-Algra5, Maas Jan Heineman4, Sjoerd Repping6, Ben Willem J Mol7, Tessa J Roseboom8, Sabine Ensing9. 1. Department of Paediatrics, Division Developmental Neurology (CA85), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address: jorienseggers@gmail.com. 2. Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Obstetrics and Gynaecology, Center for Reproductive Medicine, University of Amsterdam, Amsterdam, the Netherlands; Department of Obstetrics and Gynaecology, Medical Center Alkmaar, Alkmaar, the Netherlands. 3. Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 4. Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 5. Department of Paediatrics, Division Developmental Neurology (CA85), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. 6. Department of Obstetrics and Gynaecology, Center for Reproductive Medicine, University of Amsterdam, Amsterdam, the Netherlands. 7. Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; School of Pediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia. 8. Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 9. Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Abstract
OBJECTIVE: To study birthweight in consecutively born sibling singletons conceived with and without in vitro fertilization (IVF) to disentangle the effects of maternal characteristics from those of the IVF treatment itself. DESIGN: Population-based study. SETTING: Not applicable. PATIENT(S): Firstborn and secondborn children from a 9-year birth cohort (1999-2007) comprising of 272,551 women who conceived two siblings. INTERVENTION(S): No intervention; children were conceived naturally or through IVF. MAIN OUTCOME MEASURE(S): Birthweight. RESULT(S): The study included 545,102 children born by natural conception (NC) or IVF with the data set obtained from the population-based Netherlands Perinatal Registry (PRN) containing information on pregnancies, deliveries, and neonatal outcomes. We used two approaches: [1] the intersibling approach and [2] the sibling-ship approach. In the first approach we included children born to four groups of mothers who conceived in the following order (numbers indicate birth order): NC1-NC2 (reference, n = 254,721), IVF1-NC2 (n = 1342), NC1-IVF2 (n = 471), and IVF1-IVF2 (n = 687). Several comparisons were made to interpret the effects of IVF and maternal characteristics separately. In the second approach, perinatal outcomes of IVF children (n = 1,813) were compared with those of their NC siblings (n = 1,813). The intersibling analyses suggested an association between maternal characteristics and a lower birthweight, with estimates of the maternal effect ranging from -7 g (95% CI, -40; 26) to -101 g (95% CI, -170; -32). Neither the intersibling analyses nor the sibling-ship analyses indicated an additional adverse effect of IVF treatment itself. CONCLUSION(S): Maternal characteristics of subfertile women are associated with a lower birthweight. In vitro fertilization treatment itself does not additionally contribute to a lower birthweight in the offspring.
OBJECTIVE: To study birthweight in consecutively born sibling singletons conceived with and without in vitro fertilization (IVF) to disentangle the effects of maternal characteristics from those of the IVF treatment itself. DESIGN: Population-based study. SETTING: Not applicable. PATIENT(S): Firstborn and secondborn children from a 9-year birth cohort (1999-2007) comprising of 272,551 women who conceived two siblings. INTERVENTION(S): No intervention; children were conceived naturally or through IVF. MAIN OUTCOME MEASURE(S): Birthweight. RESULT(S): The study included 545,102 children born by natural conception (NC) or IVF with the data set obtained from the population-based Netherlands Perinatal Registry (PRN) containing information on pregnancies, deliveries, and neonatal outcomes. We used two approaches: [1] the intersibling approach and [2] the sibling-ship approach. In the first approach we included children born to four groups of mothers who conceived in the following order (numbers indicate birth order): NC1-NC2 (reference, n = 254,721), IVF1-NC2 (n = 1342), NC1-IVF2 (n = 471), and IVF1-IVF2 (n = 687). Several comparisons were made to interpret the effects of IVF and maternal characteristics separately. In the second approach, perinatal outcomes of IVFchildren (n = 1,813) were compared with those of their NC siblings (n = 1,813). The intersibling analyses suggested an association between maternal characteristics and a lower birthweight, with estimates of the maternal effect ranging from -7 g (95% CI, -40; 26) to -101 g (95% CI, -170; -32). Neither the intersibling analyses nor the sibling-ship analyses indicated an additional adverse effect of IVF treatment itself. CONCLUSION(S): Maternal characteristics of subfertile women are associated with a lower birthweight. In vitro fertilization treatment itself does not additionally contribute to a lower birthweight in the offspring.
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