Literature DB >> 26654597

A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.

E A Dukhanina1,2, T I Lukyanova1,3, E A Romanova1, V Guerriero4, N V Gnuchev1, G P Georgiev1, D V Yashin1, L P Sashchenko1.   

Abstract

PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7-Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4(+) and CD8(+) lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.

Entities:  

Keywords:  Mts1; NK cells; Tag7; Tag7-Mts1 complex; chemotaxis; human lymphocytes

Mesh：

Substances：

Year:  2015        PMID： 26654597      PMCID： PMC4825719          DOI： 10.1080/15384101.2015.1104440

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  32 in total

Review 1.  Chemokine control of lymphocyte trafficking: a general overview.

Authors:  Jens V Stein; César Nombela-Arrieta
Journal:  Immunology       Date:  2005-09       Impact factor: 7.397

2.  Comparative analysis of secretion of S100A4 metastatic marker by immune and tumor cells.

Authors:  E A Dukhanina; T I Lukyanova; E A Romanova; A S Dukhanin; L P Sashchenko
Journal:  Bull Exp Biol Med       Date:  2008-01       Impact factor: 0.804

3.  Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.

Authors:  Denis V Yashin; Elena A Dukhanina; Olga D Kabanova; Elena A Romanova; Tamara I Lukyanova; Alexsander G Tonevitskii; Alexey A Belogurov; Deborah A Raynes; Anton A Sheludchenkov; Nikolai V Gnuchev; Vince Guerriero; Georgii P Georgiev; Lidia P Sashchenko
Journal:  Biochimie       Date:  2011-10-21       Impact factor: 4.079

4.  Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.

Authors:  Rongjin Guan; Qian Wang; Eric J Sundberg; Roy A Mariuzza
Journal:  J Mol Biol       Date:  2005-04-08       Impact factor: 5.469

5.  Phenothiazines inhibit S100A4 function by inducing protein oligomerization.

Authors:  Vladimir N Malashkevich; Natalya G Dulyaninova; Udupi A Ramagopal; Melissa A Liriano; Kristen M Varney; David Knight; Michael Brenowitz; David J Weber; Steven C Almo; Anne R Bresnick
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

6.  Opposite roles of metastasin (S100A4) in two potentially tumoricidal mechanisms involving human lymphocyte protein Tag7 and Hsp70.

Authors:  Elena A Dukhanina; Olga D Kabanova; Tamara I Lukyanova; Yury V Shatalov; Denis V Yashin; Elena A Romanova; Nikolai V Gnuchev; Alexander V Galkin; Georgii P Georgiev; Lidia P Sashchenko
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-03       Impact factor: 11.205

7.  The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.

Authors:  Denis V Yashin; Elena A Dukhanina; Olga D Kabanova; Elena A Romanova; Tamara I Lukyanova; Alexsander G Tonevitskii; Deborah A Raynes; Nikolai V Gnuchev; Vince Guerriero; Georgii P Georgiev; Lidia P Sashchenko
Journal:  J Biol Chem       Date:  2011-01-19       Impact factor: 5.157

8.  Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing.

Authors:  Lidia P Sashchenko; Elena A Dukhanina; Yury V Shatalov; Denis V Yashin; Tamara I Lukyanova; Olga D Kabanova; Elena A Romanova; Sergei V Khaidukov; Alexander V Galkin; Nikolai V Gnuchev; Georgii P Georgiev
Journal:  Blood       Date:  2007-06-05       Impact factor: 22.113

9.  Unexpected deeds of familiar proteins: Interplay of Hsp70, PGRP-S/Tag7 and S100A4/Mts1 in host vs. cancer combat.

Authors:  Elena A Dukhanina; Denis V Yashin; Alexander V Galkin; Lidia P Sashchenko
Journal:  Cell Cycle       Date:  2010-03-02       Impact factor: 4.534

10.  Administration of the cytotoxic complex Tag7-Hsp70 to mice with transplanted tumors inhibits tumor growth.

Authors:  E A Dukhanina; D V Yashin; T I Lukjanova; E A Romanova; O D Kabanova; Yu V Shatalov; L P Sashchenko; N V Gnuchev
Journal:  Dokl Biol Sci       Date:  2007 May-Jun
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  12 in total

1.  Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity.

Authors:  E A Romanova; E A Dukhanina; T N Sharapova; L P Sashchenko; N V Gnuchev; D V Yashin
Journal:  Dokl Biol Sci       Date:  2017-04-21

2.  The role of S100A4 protein in anticancer cytotoxicity: its presence is required on the surface of CD4+CD25+PGRPs+S100A4+ lymphocyte and undesirable on the surface of target cells.

Authors:  E A Dukhanina; T I Lukyanova; A S Dukhanin; S G Georgieva
Journal:  Cell Cycle       Date:  2018-02-08       Impact factor: 4.534

Review 3.  Membrane heat shock protein 70: a theranostic target for cancer therapy.

Authors:  Maxim Shevtsov; Gao Huile; Gabriele Multhoff
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-01-19       Impact factor: 6.237

4.  Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.

Authors:  Anshu Shrivastav; Alexander N Dabrowski; Claudia Conrad; Nelli Baal; Holger Hackstein; Stephanie Plog; Kristina Dietert; Achim D Gruber; Philippe D N'Guessan; Sahar Aly; Norbert Suttorp; Janine Zahlten
Journal:  Front Microbiol       Date:  2018-02-01       Impact factor: 5.640

5.  Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity.

Authors:  T N Sharapova; E A Romanova; L P Sashchenko; D V Yashin
Journal:  J Immunol Res       Date:  2018-04-11       Impact factor: 4.818

6.  Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection.

Authors:  Alexander N Dabrowski; Claudia Conrad; Ulrike Behrendt; Anshu Shrivastav; Nelli Baal; Sandra M Wienhold; Holger Hackstein; Philippe D N'Guessan; Sahar Aly; Katrin Reppe; Norbert Suttorp; Janine Zahlten
Journal:  Front Microbiol       Date:  2019-02-19       Impact factor: 5.640

7.  Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

Authors:  T N Sharapova; E A Romanova; L P Sashchenko; D V Yashin
Journal:  Acta Naturae       Date:  2018 Oct-Dec       Impact factor: 1.845

8.  Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lungs by Control of the Gut Microbiota.

Authors:  Alexander N Dabrowski; Anshu Shrivastav; Claudia Conrad; Kassandra Komma; Markus Weigel; Kristina Dietert; Achim D Gruber; Wilhelm Bertrams; Jochen Wilhelm; Bernd Schmeck; Katrin Reppe; Philippe D N'Guessan; Sahar Aly; Norbert Suttorp; Torsten Hain; Janine Zahlten
Journal:  Front Immunol       Date:  2019-09-20       Impact factor: 7.561

9.  Myeloid cell interferon responses correlate with clearance of SARS-CoV-2.

Authors:  Dhiraj Singh; Ekaterina Aladyeva; Shibali Das; Bindu Singh; Ekaterina Esaulova; Amanda Swain; Mushtaq Ahmed; Journey Cole; Chivonne Moodley; Smriti Mehra; Larry Schlesinger; Maxim Artyomov; Shabaana Khader; Deepak Kaushal
Journal:  Res Sq       Date:  2021-07-15

10.  A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death.

Authors:  Elena A Romanova; Tatiana N Sharapova; Georgii B Telegin; Alexei N Minakov; Alexander S Chernov; Olga K Ivanova; Maxim L Bychkov; Lidia P Sashchenko; Denis V Yashin
Journal:  Cells       Date:  2020-02-20       Impact factor: 6.600
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