Literature DB >> 28429264

Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity.

E A Romanova1, E A Dukhanina1, T N Sharapova1, L P Sashchenko1, N V Gnuchev1, D V Yashin2.   

Abstract

Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7-Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7-Hsp70 complex, which is accompanied by a loss of both the Tag7-Mts1-mediated lymphocyte chemotaxis and the ability to release this chemoattractant into the conditioned medium.

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Year:  2017        PMID： 28429264     DOI： 10.1134/S0012496617010094

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  9 in total

1.  [Cloning of the tag7 gene expressed in metastatic mouse tumors].

Authors:  O S Kustikova; S L Kiselev; O R Borodulina; V M Senin; A V Afanas'eva; A A Kabishev
Journal:  Genetika       Date:  1996-05

2.  Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.

Authors:  C Liu; Z Xu; D Gupta; R Dziarski
Journal:  J Biol Chem       Date:  2001-07-18       Impact factor: 5.157

3.  Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein.

Authors:  T Michel; J M Reichhart; J A Hoffmann; J Royet
Journal:  Nature       Date:  2001-12-13       Impact factor: 49.962

4.  The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.

Authors:  Denis V Yashin; Elena A Dukhanina; Olga D Kabanova; Elena A Romanova; Tamara I Lukyanova; Alexsander G Tonevitskii; Deborah A Raynes; Nikolai V Gnuchev; Vince Guerriero; Georgii P Georgiev; Lidia P Sashchenko
Journal:  J Biol Chem       Date:  2011-01-19       Impact factor: 5.157

5.  A peptidoglycan recognition protein in innate immunity conserved from insects to humans.

Authors:  D Kang; G Liu; A Lundström; E Gelius; H Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

6.  A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.

Authors:  E A Dukhanina; T I Lukyanova; E A Romanova; V Guerriero; N V Gnuchev; G P Georgiev; D V Yashin; L P Sashchenko
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

Review 7.  Gene transfer approaches in cancer immunotherapy.

Authors:  S S Larin; G P Georgiev; S L Kiselev
Journal:  Gene Ther       Date:  2004-10       Impact factor: 5.250

8.  Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing.

Authors:  Lidia P Sashchenko; Elena A Dukhanina; Yury V Shatalov; Denis V Yashin; Tamara I Lukyanova; Olga D Kabanova; Elena A Romanova; Sergei V Khaidukov; Alexander V Galkin; Nikolai V Gnuchev; Georgii P Georgiev
Journal:  Blood       Date:  2007-06-05       Impact factor: 22.113

9.  Peptidoglycan recognition protein tag7 forms a cytotoxic complex with heat shock protein 70 in solution and in lymphocytes.

Authors:  Lidia P Sashchenko; Elena A Dukhanina; Denis V Yashin; Yurii V Shatalov; Elena A Romanova; Elena V Korobko; Alexander V Demin; Tamara I Lukyanova; Olga D Kabanova; Sergei V Khaidukov; Sergei L Kiselev; Alexander G Gabibov; Nikolai V Gnuchev; Georgii P Georgiev
Journal:  J Biol Chem       Date:  2003-10-29       Impact factor: 5.157
  9 in total
  1 in total

1.  Cytokines TNFα, IFNγ and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes.

Authors:  Tatiana N Sharapova; Elena A Romanova; Olga K Ivanova; Lidia P Sashchenko; Denis V Yashin
Journal:  Cells       Date:  2020-12-04       Impact factor: 6.600
  1 in total

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