Literature DB >> 26647853

Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays.

D Pihíková1, Š Belicky, P Kasák, T Bertok, J Tkac.   

Abstract

This study presents a proof-of-concept for the development of an impedimetric biosensor for ultra-sensitive glycoprofiling of prostate specific antigen (PSA). The biosensor exhibits three unique characteristics: (1) analysis of PSA with limit of detection (LOD) down to 4 aM; (2) analysis of the glycan part of PSA with LOD down to 4 aM level and; (3) both assays (i.e., PSA quantification and PSA glycoprofiling) can be performed on the same interface due to label-free analysis.

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Year:  2015        PMID： 26647853      PMCID： PMC4884444          DOI： 10.1039/c5an02322j

Source DB:  PubMed          Journal:  Analyst        ISSN： 0003-2654            Impact factor:   4.616


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