Literature DB >> 26646495

Translational strategies in aging and age-related disease.

Mary Armanios1, Rafael de Cabo2, Joan Mannick3, Linda Partridge4, Jan van Deursen5,6, Saul Villeda7,8.   

Abstract

Aging is a risk factor for several of the world's most prevalent diseases, including neurodegenerative disorders, cancer, cardiovascular disease and metabolic disease. Although our understanding of the molecular pathways that contribute to the aging process and age-related disease is progressing through the use of model organisms, how to apply this knowledge in the clinic is less clear. In September, Nature Medicine, in collaboration with the Volkswagen Foundation, hosted a conference at the beautiful Herrenhausen Palace in Hannover, Germany with the goal of broadening our understanding of the aging process and its meaning as a 'risk factor' in disease. Here, several of the speakers at that conference answer questions posed by Nature Medicine.

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Year:  2015        PMID: 26646495      PMCID: PMC8785908          DOI: 10.1038/nm.4004

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  24 in total

Review 1.  Testing the right target and right drug at the right stage.

Authors:  Reisa A Sperling; Clifford R Jack; Paul S Aisen
Journal:  Sci Transl Med       Date:  2011-11-30       Impact factor: 17.956

2.  Medical research: treat ageing.

Authors:  Luigi Fontana; Brian K Kennedy; Valter D Longo; Douglas Seals; Simon Melov
Journal:  Nature       Date:  2014-07-24       Impact factor: 49.962

3.  Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis.

Authors:  Marianna Sadagurski; Taylor Landeryou; Manuel Blandino-Rosano; Gillian Cady; Lynda Elghazi; Daniel Meister; Lauren See; Andrzej Bartke; Ernesto Bernal-Mizrachi; Richard A Miller
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-04-15       Impact factor: 4.310

4.  Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial.

Authors:  Luigi Fontana; Dennis T Villareal; Edward P Weiss; Susan B Racette; Karen Steger-May; Samuel Klein; John O Holloszy
Journal:  Am J Physiol Endocrinol Metab       Date:  2007-03-27       Impact factor: 4.310

5.  mTOR inhibition improves immune function in the elderly.

Authors:  Joan B Mannick; Giuseppe Del Giudice; Maria Lattanzi; Nicholas M Valiante; Jens Praestgaard; Baisong Huang; Michael A Lonetto; Holden T Maecker; John Kovarik; Simon Carson; David J Glass; Lloyd B Klickstein
Journal:  Sci Transl Med       Date:  2014-12-24       Impact factor: 17.956

6.  Geroscience: linking aging to chronic disease.

Authors:  Brian K Kennedy; Shelley L Berger; Anne Brunet; Judith Campisi; Ana Maria Cuervo; Elissa S Epel; Claudio Franceschi; Gordon J Lithgow; Richard I Morimoto; Jeffrey E Pessin; Thomas A Rando; Arlan Richardson; Eric E Schadt; Tony Wyss-Coray; Felipe Sierra
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

7.  Quantification of biological aging in young adults.

Authors:  Daniel W Belsky; Avshalom Caspi; Renate Houts; Harvey J Cohen; David L Corcoran; Andrea Danese; HonaLee Harrington; Salomon Israel; Morgan E Levine; Jonathan D Schaefer; Karen Sugden; Ben Williams; Anatoli I Yashin; Richie Poulton; Terrie E Moffitt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-06       Impact factor: 11.205

8.  Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.

Authors:  Chen-Yu Liao; Brad A Rikke; Thomas E Johnson; Vivian Diaz; James F Nelson
Journal:  Aging Cell       Date:  2009-10-30       Impact factor: 9.304

Review 9.  The short and long telomere syndromes: paired paradigms for molecular medicine.

Authors:  Susan E Stanley; Mary Armanios
Journal:  Curr Opin Genet Dev       Date:  2015-07-29       Impact factor: 5.578

Review 10.  Caloric restriction mimetics: towards a molecular definition.

Authors:  Frank Madeo; Federico Pietrocola; Tobias Eisenberg; Guido Kroemer
Journal:  Nat Rev Drug Discov       Date:  2014-09-12       Impact factor: 84.694

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  10 in total

Review 1.  Mitochondrial health, the epigenome and healthspan.

Authors:  Miguel A Aon; Sonia Cortassa; Magdalena Juhaszova; Steven J Sollott
Journal:  Clin Sci (Lond)       Date:  2016-08-01       Impact factor: 6.124

2.  Repurposing FDA-approved drugs for anti-aging therapies.

Authors:  Terry W Snell; Rachel K Johnston; Bharath Srinivasan; Hongyi Zhou; Mu Gao; Jeffrey Skolnick
Journal:  Biogerontology       Date:  2016-08-02       Impact factor: 4.277

3.  Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Authors:  Tea Shavlakadze; Jiang Zhu; Sharon Wang; Weihua Zhou; Bret Morin; Marc A Egerman; Lin Fan; Yanqun Wang; Oleg Iartchouk; Angelika Meyer; Reginald A Valdez; Joan B Mannick; Lloyd B Klickstein; David J Glass
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2018-06-14       Impact factor: 6.053

4.  Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia.

Authors:  Giselle A Joseph; Sharon X Wang; Cody E Jacobs; Weihua Zhou; Garrett C Kimble; Herman W Tse; John K Eash; Tea Shavlakadze; David J Glass
Journal:  Mol Cell Biol       Date:  2019-09-11       Impact factor: 4.272

5.  Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1α Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.

Authors:  Yan-Long Tang; Cheng-Gui Zhang; Heng Liu; Yue Zhou; Ya-Ping Wang; Yuan Li; Yan-Jun Han; Cui-Li Wang
Journal:  Med Sci Monit       Date:  2020-02-10

Review 6.  Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities.

Authors:  Shuling Song; Tamara Tchkonia; Jing Jiang; James L Kirkland; Yu Sun
Journal:  Adv Sci (Weinh)       Date:  2020-10-19       Impact factor: 16.806

7.  An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer.

Authors:  Jing Yuan; Fangfang Duan; Wenyu Zhai; Chenge Song; Li Wang; Wen Xia; Xin Hua; Zhongyu Yuan; Xiwen Bi; Jiajia Huang
Journal:  Int J Womens Health       Date:  2021-11-03

8.  An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Lung Squamous Carcinoma.

Authors:  Wen-Yu Zhai; Fang-Fang Duan; Si Chen; Jun-Ye Wang; Ze-Rui Zhao; Yi-Zhi Wang; Bing-Yu Rao; Yao-Bin Lin; Hao Long
Journal:  Front Cell Dev Biol       Date:  2022-03-01

9.  Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.

Authors:  Xueli Cao; Yujuan Sun; Yanfei Lin; Yanjun Pan; Umer Farooq; Lan Xiang; Jianhua Qi
Journal:  Oxid Med Cell Longev       Date:  2018-03-25       Impact factor: 6.543

10.  Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.

Authors:  Terry W Snell; Rachel K Johnston; Amelia B Matthews; Hongyi Zhou; Mu Gao; Jeffrey Skolnick
Journal:  Biogerontology       Date:  2018-01-16       Impact factor: 4.277

  10 in total

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