| Literature DB >> 26232116 |
Susan E Stanley1, Mary Armanios2.
Abstract
Recent advances have defined a role for abnormally short telomeres in a broad spectrum of genetic disorders. They include rare conditions such as dyskeratosis congenita as well pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers, such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the significance of these short and long telomere length extremes for understanding the molecular basis of age-related disease and cancer.Entities:
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Year: 2015 PMID： 26232116 PMCID： PMC4741306 DOI： 10.1016/j.gde.2015.06.004
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578