Stéphanie Bricq1, Julien Frandon2, Monique Bernard3, Maxime Guye3, Mathieu Finas2, Laetitia Marcadet4, Lucile Miquerol4, Frank Kober3, Gilbert Habib5, Daniel Fagret6, Alexis Jacquier3,7, Alain Lalande1,8. 1. Le2i, UMR 6306, CNRS, Arts et Métiers, Université de Bourgogne Franche-Comté, Dijon, France. 2. Service de radiologie, CHU, Grenoble, France. 3. Aix-Marseille Université, CNRS, CRMBM UMR 7339, Marseille, France. 4. Aix-Marseille Université, CNRS, IBDM UMR 7288, Marseille, France. 5. Département de Cardiologie, Hôpital de La Timone, AP-HM, Aix-Marseille Université, Marseille, France. 6. Service de Médecine Nucléaire, CHU, Grenoble, France. 7. Département de Radiologie, Aix Marseille Université, Hôpital Universitaire La Timone, Marseille, France. 8. Service d'IRM, CHU, Dijon, France.
Abstract
PURPOSE: To propose, assess, and validate a semiautomatic method allowing rapid and reproducible measurement of trabeculated and compacted left ventricular (LV) masses from cardiac magnetic resonance imaging (MRI). MATERIALS AND METHODS: We developed a method to automatically detect noncompacted, endocardial, and epicardial contours. Papillary muscles were segmented using semiautomatic thresholding and were included in the compacted mass. Blood was removed from trabeculae using the same threshold tool. Trabeculated, compacted masses and ratio of noncompacted to compacted (NC:C) masses were computed. Preclinical validation was performed on four transgenic mice with hypertrabeculation of the LV (high-resolution cine imaging, 11.75T). Then analysis was performed on normal cine-MRI examinations (steady-state free precession [SSFP] sequences, 1.5T or 3T) obtained from 60 healthy participants (mean age 49 ± 16 years) with 10 men and 10 women for each of the following age groups: [20,39], [40,59], and [60,79]. Interobserver and interexamination segmentation reproducibility was assessed by using Bland-Altman analysis and by computing the correlation coefficient. RESULTS: In normal participants, noncompacted and compacted masses were 6.29 ± 2.03 g/m(2) and 62.17 ± 11.32 g/m(2) , respectively. The NC:C mass ratio was 10.26 ± 3.27%. Correlation between the two observers was from 0.85 for NC:C ratio to 0.99 for end-diastolic volume (P < 10(-5) ). The bias between the two observers was -1.06 ± 1.02 g/m(2) for trabeculated mass, -1.41 ± 2.78 g/m(2) for compacted mass, and -1.51 ± 1.77% for NC:C ratio. CONCLUSION: We propose a semiautomatic method based on region growing, active contours, and thresholding to calculate the NC:C mass ratio. This method is highly reproducible and might help in the diagnosis of LV noncompaction cardiomyopathy. J. Magn. Reson. Imaging 2016;43:1398-1406.
PURPOSE: To propose, assess, and validate a semiautomatic method allowing rapid and reproducible measurement of trabeculated and compacted left ventricular (LV) masses from cardiac magnetic resonance imaging (MRI). MATERIALS AND METHODS: We developed a method to automatically detect noncompacted, endocardial, and epicardial contours. Papillary muscles were segmented using semiautomatic thresholding and were included in the compacted mass. Blood was removed from trabeculae using the same threshold tool. Trabeculated, compacted masses and ratio of noncompacted to compacted (NC:C) masses were computed. Preclinical validation was performed on four transgenic mice with hypertrabeculation of the LV (high-resolution cine imaging, 11.75T). Then analysis was performed on normal cine-MRI examinations (steady-state free precession [SSFP] sequences, 1.5T or 3T) obtained from 60 healthy participants (mean age 49 ± 16 years) with 10 men and 10 women for each of the following age groups: [20,39], [40,59], and [60,79]. Interobserver and interexamination segmentation reproducibility was assessed by using Bland-Altman analysis and by computing the correlation coefficient. RESULTS: In normal participants, noncompacted and compacted masses were 6.29 ± 2.03 g/m(2) and 62.17 ± 11.32 g/m(2) , respectively. The NC:C mass ratio was 10.26 ± 3.27%. Correlation between the two observers was from 0.85 for NC:C ratio to 0.99 for end-diastolic volume (P < 10(-5) ). The bias between the two observers was -1.06 ± 1.02 g/m(2) for trabeculated mass, -1.41 ± 2.78 g/m(2) for compacted mass, and -1.51 ± 1.77% for NC:C ratio. CONCLUSION: We propose a semiautomatic method based on region growing, active contours, and thresholding to calculate the NC:C mass ratio. This method is highly reproducible and might help in the diagnosis of LV noncompaction cardiomyopathy. J. Magn. Reson. Imaging 2016;43:1398-1406.
Authors: Andrew D'Silva; Gabriella Captur; Anish N Bhuva; Siana Jones; Rachel Bastiaenen; Amna Abdel-Gadir; Sabiha Gati; Jet van Zalen; James Willis; Aneil Malhotra; Irina Chis Ster; Charlotte Manisty; Alun D Hughes; Guy Lloyd; Rajan Sharma; James C Moon; Sanjay Sharma Journal: Int J Cardiol Date: 2020-04-29 Impact factor: 4.164
Authors: Marcelo Dantas Tavares de Melo; Jose de Arimatéia Batista Araujo-Filho; José Raimundo Barbosa; Camila Rocon; Carlos Danilo Miranda Regis; Alex Dos Santos Felix; Roberto Kalil Filho; Edimar Alcides Bocchi; Ludhmila Abrahão Hajjar; Mahdi Tabassian; Jan D'hooge; Vera Maria Cury Salemi Journal: PLoS One Date: 2021-11-29 Impact factor: 3.240