Vahe Bandarian1, Catherine L Drennan2. 1. Department of Chemistry, University of Utah, Salt Lake City, UT 84112, United States. Electronic address: vahe@chem.utah.edu. 2. Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemistry, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Abstract
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
Pyrrolopyrimidine containing natural products are widely distributed inn class="Chemical">Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
Authors: H Kasai; Z Oashi; F Harada; S Nishimura; N J Oppenheimer; P F Crain; J G Liehr; D L von Minden; J A McCloskey Journal: Biochemistry Date: 1975-09-23 Impact factor: 3.162