Literature DB >> 26641771

An emerging role for cytopathology in precision oncology.

Chantal Pauli1,2, Loredana Puca1,2, Juan Miguel Mosquera1,2, Brian D Robinson1,2, Himisha Beltran1,3, Mark A Rubin1,2,3, Rema A Rao1,2.   

Abstract

Precision medicine is an emerging field in medicine for disease prevention and treatment that takes into account the individual variability in genes, environment, and lifestyle for each individual patient. The authors have developed a special program as part of the Englander Institute for Precision Medicine to grow patient-derived, 3-dimensional tumor organoids for tumor-specific drug testing, tailoring treatment strategies, and as models for studying drug resistance. Routine cytology preparations represent a cost-effective and powerful tool to aid in performing molecular testing in the age of personalized medicine. In this commentary, the platforms used for the characterization and validation of patient-derived, 3-dimensional tumor organoids are outlined and discussed, and the role of cytology as a cost-effective and powerful quality-control measure is illustrated.
© 2015 American Cancer Society.

Entities:  

Keywords:  3-dimensional (3D) tumor organoid; cytology; cytology smear; in vitro models; next-generation sequencing; organoids; precision medicine

Mesh：

Year:  2015        PMID： 26641771     DOI： 10.1002/cncy.21647

Source DB:  PubMed          Journal:  Cancer Cytopathol        ISSN： 1934-662X            Impact factor:   5.284


  9 in total

Review 1.  [Establishment of a living biobank : Improved guidance of precision cancer care with in vitro and in vivo cancer models].

Authors:  C Pauli; H Moch; M A Rubin
Journal:  Pathologe       Date:  2017-11       Impact factor: 1.011

2.  Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.

Authors:  Chantal Pauli; Benjamin D Hopkins; Davide Prandi; Reid Shaw; Tarcisio Fedrizzi; Andrea Sboner; Verena Sailer; Michael Augello; Loredana Puca; Rachele Rosati; Terra J McNary; Yelena Churakova; Cynthia Cheung; Joanna Triscott; David Pisapia; Rema Rao; Juan Miguel Mosquera; Brian Robinson; Bishoy M Faltas; Brooke E Emerling; Vijayakrishna K Gadi; Brady Bernard; Olivier Elemento; Himisha Beltran; Francesca Demichelis; Christopher J Kemp; Carla Grandori; Lewis C Cantley; Mark A Rubin
Journal:  Cancer Discov       Date:  2017-03-22       Impact factor: 39.397

Review 3.  Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies.

Authors:  Loredana Puca; Panagiotis J Vlachostergios; Himisha Beltran
Journal:  Cold Spring Harb Perspect Med       Date:  2019-02-01       Impact factor: 6.915

Review 4.  Emerging Variants of Castration-Resistant Prostate Cancer.

Authors:  Panagiotis J Vlachostergios; Loredana Puca; Himisha Beltran
Journal:  Curr Oncol Rep       Date:  2017-05       Impact factor: 5.075

5.  Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Authors:  Benjamin D Hopkins; Chantal Pauli; Xing Du; Diana G Wang; Xiang Li; David Wu; Solomon C Amadiume; Marcus D Goncalves; Cindy Hodakoski; Mark R Lundquist; Rohan Bareja; Yan Ma; Emily M Harris; Andrea Sboner; Himisha Beltran; Mark A Rubin; Siddhartha Mukherjee; Lewis C Cantley
Journal:  Nature       Date:  2018-07-04       Impact factor: 49.962

6.  Patient derived organoids to model rare prostate cancer phenotypes.

Authors:  Loredana Puca; Rohan Bareja; Davide Prandi; Reid Shaw; Matteo Benelli; Wouter R Karthaus; Judy Hess; Michael Sigouros; Adam Donoghue; Myriam Kossai; Dong Gao; Joanna Cyrta; Verena Sailer; Aram Vosoughi; Chantal Pauli; Yelena Churakova; Cynthia Cheung; Lesa Dayal Deonarine; Terra J McNary; Rachele Rosati; Scott T Tagawa; David M Nanus; Juan Miguel Mosquera; Charles L Sawyers; Yu Chen; Giorgio Inghirami; Rema A Rao; Carla Grandori; Olivier Elemento; Andrea Sboner; Francesca Demichelis; Mark A Rubin; Himisha Beltran
Journal:  Nat Commun       Date:  2018-06-19       Impact factor: 14.919

7.  Cancer Sample Biobanking at the Next Level: Combining Tissue With Living Cell Repositories to Promote Precision Medicine.

Authors:  Hella A Bolck; Chantal Pauli; Elisabeth Göbel; Katharina Mühlbauer; Susanne Dettwiler; Holger Moch; Peter Schraml
Journal:  Front Cell Dev Biol       Date:  2019-10-22

8.  Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models.

Authors:  David J Pisapia; Steven Salvatore; Chantal Pauli; Erika Hissong; Ken Eng; Davide Prandi; Verena-Wilbeth Sailer; Brian D Robinson; Kyung Park; Joanna Cyrta; Scott T Tagawa; Myriam Kossai; Jacqueline Fontugne; Robert Kim; Alexandros Sigaras; Rema Rao; Danielle Pancirer; Bishoy Faltas; Rohan Bareja; Ana M Molina; David M Nanus; Prajwal Rajappa; Mark M Souweidane; Jeffrey Greenfield; Anne-Katrin Emde; Nicolas Robine; Olivier Elemento; Andrea Sboner; Francesca Demichelis; Himisha Beltran; Mark A Rubin; Juan Miguel Mosquera
Journal:  JCO Precis Oncol       Date:  2017-06-14

9.  Microdissected "cuboids" for microfluidic drug testing of intact tissues.

Authors:  Lisa F Horowitz; Adan D Rodriguez; Allan Au-Yeung; Kevin W Bishop; Lindsey A Barner; Gargi Mishra; Aashik Raman; Priscilla Delgado; Jonathan T C Liu; Taranjit S Gujral; Mehdi Mehrabi; Mengsu Yang; Robert H Pierce; Albert Folch
Journal:  Lab Chip       Date:  2021-01-05       Impact factor: 6.799
  9 in total

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