Literature DB >> 26634024

Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy.

Roman A Sukhovershin1, Gautham Yepuri1, Yohannes T Ghebremariam1.   

Abstract

Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

Entities:  

Keywords:  antiatherogenic; asymmetric dimethylarginine; atherosclerosis; dimethylarginine dimethylaminohydrolase; endothelial nitric oxide synthase; endothelium; nitric oxide; vascular dysfunction

Mesh：

Substances：

Year:  2015        PMID： 26634024      PMCID： PMC4666423          DOI： 10.14797/mdcj-11-3-166

Source DB:  PubMed          Journal:  Methodist Debakey Cardiovasc J        ISSN： 1947-6108


  45 in total

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Authors:  Erling Falk
Journal:  J Am Coll Cardiol       Date:  2006-04-18       Impact factor: 24.094

Review 2.  Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis.

Authors:  Arnold G Herman; Salvador Moncada
Journal:  Eur Heart J       Date:  2005-05-23       Impact factor: 29.983

Review 3.  Endogenous production of nitric oxide synthase inhibitors.

Authors:  Shelagh Anthony; James Leiper; Patrick Vallance
Journal:  Vasc Med       Date:  2005-07       Impact factor: 3.239

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Journal:  Circulation       Date:  1998-03-31       Impact factor: 29.690

5.  Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells.

Authors:  Phillip A Erwin; Alison J Lin; David E Golan; Thomas Michel
Journal:  J Biol Chem       Date:  2005-03-17       Impact factor: 5.157

6.  Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque.

Authors:  C Depre; X Havaux; J Renkin; J L Vanoverschelde; W Wijns
Journal:  Cardiovasc Res       Date:  1999-02       Impact factor: 10.787

7.  Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.

Authors:  Sungwoo Ryoo; Christopher A Lemmon; Kevin G Soucy; Gaurav Gupta; Anthony R White; Daniel Nyhan; Artin Shoukas; Lewis H Romer; Dan E Berkowitz
Journal:  Circ Res       Date:  2006-09-28       Impact factor: 17.367

8.  Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase.

Authors:  Karel Chalupsky; Hua Cai
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-07       Impact factor: 11.205

9.  Nitric oxide regulates monocyte chemotactic protein-1.

Authors:  P S Tsao; B Wang; R Buitrago; J Y Shyy; J P Cooke
Journal:  Circulation       Date:  1997-08-05       Impact factor: 29.690

Review 10.  Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.

Authors:  Fredrik Palm; Maristela L Onozato; Zaiming Luo; Christopher S Wilcox
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-10-12       Impact factor: 4.733
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  14 in total

1.  Metabolic syndrome is negatively associated with cognition among endothelial nitric oxide synthase (eNOS)- 786C carriers in schizophrenia-spectrum disorders.

Authors:  A Zarina Kraal; Allison C Moll; Nicole R Arvanitis; Kristen M Ward; Ryan J Dougherty; Tyler B Grove; Kyle J Burghardt; Vicki L Ellingrod
Journal:  J Psychiatr Res       Date:  2019-07-26       Impact factor: 4.791

2.  Anti inflammatory effect of asiaticoside on human umbilical vein endothelial cells induced by ox-LDL.

Authors:  Li Jing; Wang Haitao; Wang Qiong; Zhu Fu; Zhang Nan; Zhang Xuezheng
Journal:  Cytotechnology       Date:  2018-02-19       Impact factor: 2.058

3.  Efficacy of continuous positive airway pressure treatment in treating obstructive sleep apnea hypopnea syndrome associated with carotid arteriosclerosis.

Authors:  Yong-Qian Jiang; Jin-Shan Xue; Juan Xu; Zhi-Xiang Zhou; You-Lin Ji
Journal:  Exp Ther Med       Date:  2017-10-16       Impact factor: 2.447

4.  Significance and Mechanistic Relevance of SIRT6-Mediated Endothelial Dysfunction in Cardiovascular Disease Progression.

Authors:  Gautham Yepuri; Ravichandran Ramasamy
Journal:  Circ Res       Date:  2019-05-10       Impact factor: 17.367

5.  Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome.

Authors:  Gianfranco Matrone; Rajarajan A Thandavarayan; Brandon K Walther; Shu Meng; Anahita Mojiri; John P Cooke
Journal:  Cell Cycle       Date:  2019-08-14       Impact factor: 4.534

Review 6.  How May Proton Pump Inhibitors Impair Cardiovascular Health?

Authors:  Roman A Sukhovershin; John P Cooke
Journal:  Am J Cardiovasc Drugs       Date:  2016-06       Impact factor: 3.571

7.  Association of eNOS 27-bp VNTR, 894G>T and 786T>C polymorphisms with susceptibility to Legg-Calve-Perthes Disease in Iranian children.

Authors:  Mohammad Reza Azarpira; Mohammad Mahdi Ghilian; Mohammad Reza Sobhan; Masoud Mahdinezhad-Yazdi; Kazem Aghili; Hossein Ahrar; Hossein Neamatzadeh
Journal:  J Orthop       Date:  2019-02-26

Review 8.  Roles of eNOS in atherosclerosis treatment.

Authors:  Fen-Fang Hong; Xiao-Yu Liang; Wei Liu; Sha Lv; Shu-Jin He; Hai-Bin Kuang; Shu-Long Yang
Journal:  Inflamm Res       Date:  2019-04-01       Impact factor: 4.575

9.  Vascular Aging: Implications for Cardiovascular Disease and Therapy.

Authors:  Yohannes T Ghebre; Eduard Yakubov; Wing Tak Wong; Prasanna Krishnamurthy; Nazish Sayed; Andrew G Sikora; Mark D Bonnen
Journal:  Transl Med (Sunnyvale)       Date:  2016-08-30

10.  Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway.

Authors:  Qiang Wan; Zhongyong Liu; Yuping Yang
Journal:  BMC Complement Altern Med       Date:  2018-05-04       Impact factor: 3.659
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