Mohammad Reza Azarpira1, Mohammad Mahdi Ghilian1, Mohammad Reza Sobhan2, Masoud Mahdinezhad-Yazdi2, Kazem Aghili3, Hossein Ahrar3, Hossein Neamatzadeh4,5. 1. Bone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2. Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 4. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
BACKGROUND: The aim of this study was to analyze the association of eNOS polymorphisms with risk of Legg-Calve-Perthes Disease (LCPD). METHODS: The study comprised of 45 LCPD patients and 55 controls. The eNOS polymorphisms were genotyped with PCR and by PCR-RFLP. RESULTS: The eNOS 894G > T and -786T > C polymorphisms were significantly associated with an increased risk of LCPD. However, there was no significant association between eNOS 27-bp VNTR polymorphism and LCPD risk. CONCLUSION: Our results suggest that the eNOS 894G > T and -786T > C polymorphisms may be a risk factor for LCPD in Iranian children, but not 27-bp VNTR polymorphism.
BACKGROUND: The aim of this study was to analyze the association of eNOS polymorphisms with risk of Legg-Calve-Perthes Disease (LCPD). METHODS: The study comprised of 45 LCPD patients and 55 controls. The eNOS polymorphisms were genotyped with PCR and by PCR-RFLP. RESULTS: The eNOS 894G > T and -786T > C polymorphisms were significantly associated with an increased risk of LCPD. However, there was no significant association between eNOS 27-bp VNTR polymorphism and LCPD risk. CONCLUSION: Our results suggest that the eNOS 894G > T and -786T > C polymorphisms may be a risk factor for LCPD in Iranian children, but not 27-bp VNTR polymorphism.
Authors: Charles J Glueck; Robert E McMahon; Jerry E Bouquot; Naseer A Khan; Ping Wang Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2010-02-24
Authors: Daniel C Perry; David M G Machin; Daniel Pope; Colin E Bruce; Peter Dangerfield; Mary Jane Platt; Andrew J Hall Journal: Am J Epidemiol Date: 2012-01-05 Impact factor: 4.897