Literature DB >> 26817947

How May Proton Pump Inhibitors Impair Cardiovascular Health?

Roman A Sukhovershin1, John P Cooke2.   

Abstract

Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an increased cardiovascular risk. In this article, we review the clinical evidence for adverse cardiovascular effects of PPIs, and we discuss possible biological mechanisms by which PPIs can impair cardiovascular health.

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Year:  2016        PMID： 26817947      PMCID： PMC4864131          DOI： 10.1007/s40256-016-0160-9

Source DB:  PubMed          Journal:  Am J Cardiovasc Drugs        ISSN： 1175-3277            Impact factor:   3.571


  86 in total

1.  Failing the acid test: benefits of proton pump inhibitors may not justify the risks for many users.

Authors:  Mitchell H Katz
Journal:  Arch Intern Med       Date:  2010-05-10

Review 2.  The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Authors:  Jon O Lundberg; Eddie Weitzberg; Mark T Gladwin
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

Review 3.  Proton pump inhibitors: the good, the bad, and the unwanted.

Authors:  Saman Chubineh; John Birk
Journal:  South Med J       Date:  2012-11       Impact factor: 0.954

4.  Proton pump inhibitor use represents an independent risk factor for myocardial infarction.

Authors:  Chia-Jen Shih; Yung-Tai Chen; Shuo-Ming Ou; Szu-Yuan Li; Tzeng-Ji Chen; Shuu-Jiun Wang
Journal:  Int J Cardiol       Date:  2014-09-28       Impact factor: 4.164

5.  Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.

Authors:  R H Böger; S M Bode-Böger; A Szuba; P S Tsao; J R Chan; O Tangphao; T F Blaschke; J P Cooke
Journal:  Circulation       Date:  1998-11-03       Impact factor: 29.690

6.  Inhibition of lysosomal enzyme activities by proton pump inhibitors.

Authors:  Wensheng Liu; Susan S Baker; Jonathan Trinidad; Alma L Burlingame; Robert D Baker; John G Forte; Lauren P Virtuoso; Nejat K Egilmez; Lixin Zhu
Journal:  J Gastroenterol       Date:  2013-03-12       Impact factor: 7.527

Review 7.  An overview of proton pump inhibitors.

Authors:  Gabriella Der
Journal:  Gastroenterol Nurs       Date:  2003 Sep-Oct       Impact factor: 0.978

8.  Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: an updated meta-analysis.

Authors:  Rhanderson N Cardoso; Alexandre M Benjo; James J DiNicolantonio; Daniel C Garcia; Francisco Y B Macedo; Georges El-Hayek; Girish N Nadkarni; Sebastiano Gili; Mario Iannaccone; Ioannis Konstantinidis; John P Reilly
Journal:  Open Heart       Date:  2015-06-30

9.  Proton pump inhibitors and the risk of adverse cardiac events.

Authors:  David N Juurlink; Colin R Dormuth; Anjie Huang; Chelsea Hellings; J Michael Paterson; Colette Raymond; Anita Kozyrskyj; Yola Moride; Erin M Macdonald; Muhammad M Mamdani
Journal:  PLoS One       Date:  2013-12-27       Impact factor: 3.240

10.  Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction.

Authors:  J P Depta; P A Lenzini; D E Lanfear; T Y Wang; J A Spertus; R G Bach; S Cresci
Journal:  Pharmacogenomics J       Date:  2014-07-08       Impact factor: 3.550
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  11 in total

Review 1.  Surgical Treatment of Gastroesophageal Reflux Disease.

Authors:  Francisco Schlottmann; Fernando A Herbella; Marco E Allaix; Fabrizio Rebecchi; Marco G Patti
Journal:  World J Surg       Date:  2017-07       Impact factor: 3.352

Review 2.  Update on assessment and management of primary cardiac involvement in systemic sclerosis.

Authors:  Vasiliki-Kalliopi Bournia; Christos Tountas; Athanase D Protogerou; Stylianos Panopoulos; Sophie Mavrogeni; Petros P Sfikakis
Journal:  J Scleroderma Relat Disord       Date:  2018-04-04

Review 3.  A Contemporary Look at Biomechanical Models of Myocardium.

Authors:  Reza Avazmohammadi; João S Soares; David S Li; Samarth S Raut; Robert C Gorman; Michael S Sacks
Journal:  Annu Rev Biomed Eng       Date:  2019-06-04       Impact factor: 9.590

4.  Association of Proton Pump Inhibitors With Higher Risk of Cardiovascular Disease and Heart Failure.

Authors:  Elizabeth J Bell; Suzette J Bielinski; Jennifer L St Sauver; Lin Y Chen; Mary R Rooney; Nicholas B Larson; Paul Y Takahashi; Aaron R Folsom
Journal:  Mayo Clin Proc       Date:  2021-10       Impact factor: 11.104

5.  Proton-pump Inhibitor Use and Fracture Risk: An Updated Systematic Review and Meta-analysis.

Authors:  Yousef Nassar; Seth Richter
Journal:  J Bone Metab       Date:  2018-08-31

Review 6.  Possible Effects of Proton Pump Inhibitors on Hearing Loss Development.

Authors:  Michał Wiciński; Bartosz Malinowski; Oskar Puk; Karol Górski; Dawid Adamkiewicz; Grzegorz Chojnacki; Maciej Walczak; Eryk Wódkiewicz; Monika Szambelan; Paulina Adamska; Kamila Skibińska; Maciej Socha; Maciej Słupski; Katarzyna Pawlak-Osińska
Journal:  Biomed Res Int       Date:  2019-10-17       Impact factor: 3.411

7.  The Association between Proton Pump Inhibitors and Myocardial Infarction: What Do Food and Drug Administration Data Tell Us?

Authors:  Jiun Ming Tan; Richard Parsons; Tin Fei Sim; Ya Ping Lee
Journal:  J Res Pharm Pract       Date:  2019-10-16

8.  Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials.

Authors:  Man Yang; Qiangsheng He; Fang Gao; Krish Nirantharakumar; Tonny Veenith; Xiwen Qin; Amy T Page; Martin C S Wong; Junjie Huang; Zi Chong Kuo; Bin Xia; Changhua Zhang; Yulong He; Wenbo Meng; Jinqiu Yuan; Yihang Pan
Journal:  BMC Med       Date:  2021-12-03       Impact factor: 8.775

9.  Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction.

Authors:  Lucas C Pinheiro; Gustavo H Oliveira-Paula; Rafael L Portella; Danielle A Guimarães; Celio D de Angelis; Jose E Tanus-Santos
Journal:  Redox Biol       Date:  2016-08-04       Impact factor: 11.799

Review 10.  Nonsteroidal anti-inflammatory drugs in chronic pain: implications of new data for clinical practice.

Authors:  Kok Yuen Ho; Kok Ann Gwee; Yew Kuang Cheng; Kam Hon Yoon; Hwan Tak Hee; Abdul Razakjr Omar
Journal:  J Pain Res       Date:  2018-09-20       Impact factor: 3.133
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