Zhen Cui1, Ye Tian2, Bin He3, Hongwei Li3, Duojie Li3, Jingjing Liu3, Hanfei Cai3, Jianjun Lou3, Hao Jiang3, Xueming Shen3, Kaigui Peng3. 1. Deptment of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215000, China ; Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China. 2. Deptment of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215000, China. 3. Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
Abstract
BACKGROUND: Radiation pneumonitis is one of the most severe complications of esophageal cancer. PURPOSE: To explore the factors correlated to radiation pneumonitis induced by precise radiotherapy for elderly patients with esophageal cancer. METHODS: The retrospective analysis was used to collect clinical data from 186 elderly patients with esophageal cancer. The incidence of radiation pneumonitis was observed, followed by statistical analysis through ANVON or multiple regression analysis. RESULTS: 27 in 186 cases of esophageal cancer suffered from radiation pneumonitis, with incidence of 14.52%. The single factor analysis showed that, Karnofsky performance status (KPS) score, chronic obstructive pulmonary disease, concurrent chemoradiotherapy, gross tumor volume (GTV) dose, lung V20, mean lung dose (MLD) and planning target volume (PTV) were associated with radiation pneumonitis. The logistic regression analysis indicated that, concurrent chemoradiotherapy, GTV dose, lung V20 and PTV were the independent factors of radiation pneumonitis. CONCLUSION: The concurrent chemoradiotherapy, GTV dose, lung V20, MLD and PTV are the major risk factors of radiation pneumonitis for elderly patients with esophageal cancer.
BACKGROUND: Radiation pneumonitis is one of the most severe complications of esophageal cancer. PURPOSE: To explore the factors correlated to radiation pneumonitis induced by precise radiotherapy for elderly patients with esophageal cancer. METHODS: The retrospective analysis was used to collect clinical data from 186 elderly patients with esophageal cancer. The incidence of radiation pneumonitis was observed, followed by statistical analysis through ANVON or multiple regression analysis. RESULTS: 27 in 186 cases of esophageal cancer suffered from radiation pneumonitis, with incidence of 14.52%. The single factor analysis showed that, Karnofsky performance status (KPS) score, chronic obstructive pulmonary disease, concurrent chemoradiotherapy, gross tumor volume (GTV) dose, lung V20, mean lung dose (MLD) and planning target volume (PTV) were associated with radiation pneumonitis. The logistic regression analysis indicated that, concurrent chemoradiotherapy, GTV dose, lung V20 and PTV were the independent factors of radiation pneumonitis. CONCLUSION: The concurrent chemoradiotherapy, GTV dose, lung V20, MLD and PTV are the major risk factors of radiation pneumonitis for elderly patients with esophageal cancer.
Authors: Yang-Gun Suh; Ik Jae Lee; Wong Sub Koom; Jihye Cha; Jong Young Lee; Soo Kon Kim; Chang Geol Lee Journal: Jpn J Clin Oncol Date: 2014-04-24 Impact factor: 3.019
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Authors: Wei Song; Hong Lu; Jie Liu; Di Zhao; Jun Ma; Biyun Zhang; Dahai Yu; Xinchen Sun; Jinkai Li Journal: J Appl Clin Med Phys Date: 2019-08-28 Impact factor: 2.102