Shigenobu Watanabe1, Ichiro Ogino2, Daisuke Shigenaga2, Masaharu Hata3. 1. Department of Radiation Oncology, Yokohama City University Medical Center, Yokohama, Japan; wata_s@yokohama-cu.ac.jp. 2. Department of Radiation Oncology, Yokohama City University Medical Center, Yokohama, Japan. 3. Department of Radiation Oncology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Abstract
BACKGROUND/AIM: It is important to identify radiation pneumonitis above Common Terminology Criteria for Adverse Events Grade 2 (G2) in order to safely continue durvalumab maintenance after chemoradiotherapy for advanced lung cancer. The aim of this study was to discover factors that predict pneumonitis above G2. PATIENTS AND METHODS: A follow-up computed tomography (CT) image was superimposed on the planning CT image using deformable image registration (DIR). The pneumonitis area was contoured on follow-up CT after DIR and the dose-volume histogram parameters of the contoured pneumonitis area were calculated. RESULTS: V5 (Percentage of total volume receiving ≥5 Gy) to V50 of pneumonitis were significantly lower in patients with G2 pneumonitis than in those with G1 pneumonitis. The pneumonitis V15 was the most significant. The group with pneumonitis V15 <87.10% had significantly more G2 pneumonitis than the group with pneumonitis V15 ≥87.10%. CONCLUSION: Pneumonitis V15 <87.10% was a risk factor for G2 pneumonitis.
BACKGROUND/AIM: It is important to identify radiation pneumonitis above Common Terminology Criteria for Adverse Events Grade 2 (G2) in order to safely continue durvalumab maintenance after chemoradiotherapy for advanced lung cancer. The aim of this study was to discover factors that predict pneumonitis above G2. PATIENTS AND METHODS: A follow-up computed tomography (CT) image was superimposed on the planning CT image using deformable image registration (DIR). The pneumonitis area was contoured on follow-up CT after DIR and the dose-volume histogram parameters of the contoured pneumonitis area were calculated. RESULTS: V5 (Percentage of total volume receiving ≥5 Gy) to V50 of pneumonitis were significantly lower in patients with G2 pneumonitis than in those with G1 pneumonitis. The pneumonitis V15 was the most significant. The group with pneumonitis V15 <87.10% had significantly more G2 pneumonitis than the group with pneumonitis V15 ≥87.10%. CONCLUSION: Pneumonitis V15 <87.10% was a risk factor for G2 pneumonitis.
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