Literature DB >> 2662183

Rat glucokinase gene: structure and regulation by insulin.

M A Magnuson1, T L Andreone, R L Printz, S Koch, D K Granner.   

Abstract

The glucokinase gene is 15.5-kilobases long, appears to be present as a single copy, and contains 10 exons that range in size from 96 to 977 base pairs. The transcription start site was located 127 nucleotides upstream from the translation initiation codon. The 5' flanking DNA contains several regions similar to defined promoter elements. These include a probable "TATA box," an Sp1 binding site, and several elements related to liver-specific gene expression. In addition, we determined that transcription of the glucokinase gene increased at least 20-fold when diabetic rats were treated with insulin for 2 hr.

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Year:  1989        PMID： 2662183      PMCID： PMC297510          DOI： 10.1073/pnas.86.13.4838

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

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Authors:  S Weinhouse
Journal:  Curr Top Cell Regul       Date:  1976

2.  Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase.

Authors:  D A Schwab; J E Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

3.  Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver.

Authors:  U Schibler; O Hagenbüchle; P K Wellauer; A C Pittet
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

4.  pEMBL: a new family of single stranded plasmids.

Authors:  L Dente; G Cesareni; R Cortese
Journal:  Nucleic Acids Res       Date:  1983-03-25       Impact factor: 16.971

Review 5.  Organization and expression of eucaryotic split genes coding for proteins.

Authors:  R Breathnach; P Chambon
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

6.  Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

Authors:  G S McKnight; R D Palmiter
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

7.  Rapid action of insulin and cyclic AMP in the regulation of functional messenger RNA coding for glucokinase in rat liver.

Authors:  W Sibrowski; H J Seitz
Journal:  J Biol Chem       Date:  1984-01-10       Impact factor: 5.157

8.  Insulin and glucagon regulate cytosolic phosphoenolpyruvate carboxykinase (GTP) mRNA in rat liver.

Authors:  E Beale; T Andreone; S Koch; M Granner; D Granner
Journal:  Diabetes       Date:  1984-04       Impact factor: 9.461

9.  Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans.

Authors:  M D Meglasson; P T Burch; D K Berner; H Najafi; A P Vogin; F M Matschinsky
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  60 in total

1.  Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP.

Authors:  M O Bergot; M J Diaz-Guerra; N Puzenat; M Raymondjean; A Kahn
Journal:  Nucleic Acids Res       Date:  1992-04-25       Impact factor: 16.971

Review 2.  Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.

Authors:  Saroj P Mathupala; Young H Ko; Peter L Pedersen
Journal:  Semin Cancer Biol       Date:  2008-12-03       Impact factor: 15.707

3.  Expression and site-directed mutagenesis of hepatic glucokinase.

Authors:  A J Lange; L Z Xu; F Van Poelwijk; K Lin; D K Granner; S J Pilkis
Journal:  Biochem J       Date:  1991-07-01       Impact factor: 3.857

Review 4.  Regulation of gene expression by insulin.

Authors:  R M O'Brien; D K Granner
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

5.  Alternative splicing of glucokinase mRNA in rat liver.

Authors:  D J Hayzer; P B Iynedjian
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

6.  Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene.

Authors:  P B Iynedjian
Journal:  Biochem J       Date:  1998-08-01       Impact factor: 3.857

7.  Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region.

Authors:  A Ruzzo; F Andreoni; M Magnani
Journal:  Biochem J       Date:  1998-04-15       Impact factor: 3.857

8.  Hexokinase as a sugar sensor in higher plants.

Authors:  J C Jang; P León; L Zhou; J Sheen
Journal:  Plant Cell       Date:  1997-01       Impact factor: 11.277

9.  Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats.

Authors:  M Tiedge; S Lenzen
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

10.  Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats.

Authors:  A Valera; J E Rodriguez-Gil; F Bosch
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808
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