Hadrien Dyvorne1, Priti Balchandani1. 1. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Abstract
PURPOSE: At high field, T2 -weighted (T2 w) imaging is limited by transmit field inhomogeneity and increased radiofrequency power deposition. In this work, we introduce SAMPA (Slice-selective Adiabatic Magnetization T2 PrepAration) and demonstrate its use for efficient brain T2 w imaging at 7 Tesla (T). METHODS: SAMPA was designed by subsampling an optimized B1 insensitive rotation (BIR4) waveform with small tip angle linear subpulses. To perform T2 w imaging, SAMPA was inserted before a fast gradient echo acquisition. The off-resonance behavior, B1 robustness, and slice selectivity of the novel T2 preparation module were analyzed using Bloch simulations. The performance of SAMPA for T2 w imaging was demonstrated in phantom experiments as well as in the brains of healthy volunteers at 7T. RESULTS: Based on simulations, the proposed design operates at peak B1 of 15 μT and higher, within a 400 Hz bandwidth. T2 values were in strong agreement with spin echo-based T2 mapping in phantom experiments. Whole brain, interleaved multislab three-dimensional imaging could be acquired with 0.8 mm3 isotropic resolution in 5:36 min per T2 weighting. CONCLUSION: Compared with previous adiabatic T2 preparation techniques, SAMPA allows for slice-selectivity, which can lead to efficient and robust acquisitions for T2 w imaging at high field. Magn Reson Med 76:1741-1749, 2016.
PURPOSE: At high field, T2 -weighted (T2 w) imaging is limited by transmit field inhomogeneity and increased radiofrequency power deposition. In this work, we introduce SAMPA (Slice-selective Adiabatic Magnetization T2 PrepAration) and demonstrate its use for efficient brain T2 w imaging at 7 Tesla (T). METHODS:SAMPA was designed by subsampling an optimized B1 insensitive rotation (BIR4) waveform with small tip angle linear subpulses. To perform T2 w imaging, SAMPA was inserted before a fast gradient echo acquisition. The off-resonance behavior, B1 robustness, and slice selectivity of the novel T2 preparation module were analyzed using Bloch simulations. The performance of SAMPA for T2 w imaging was demonstrated in phantom experiments as well as in the brains of healthy volunteers at 7T. RESULTS: Based on simulations, the proposed design operates at peak B1 of 15 μT and higher, within a 400 Hz bandwidth. T2 values were in strong agreement with spin echo-based T2 mapping in phantom experiments. Whole brain, interleaved multislab three-dimensional imaging could be acquired with 0.8 mm3 isotropic resolution in 5:36 min per T2 weighting. CONCLUSION: Compared with previous adiabatic T2 preparation techniques, SAMPA allows for slice-selectivity, which can lead to efficient and robust acquisitions for T2 w imaging at high field. Magn Reson Med 76:1741-1749, 2016.
Authors: Elizabeth R Jenista; Wolfgang G Rehwald; Enn-Ling Chen; Han W Kim; Igor Klem; Michele A Parker; Raymond J Kim Journal: Magn Reson Med Date: 2012-12-04 Impact factor: 4.668