BACKGROUND: Current data suggest that the 2 common tremor disorders, essential tremor (ET) and Parkinson's disease (PD), may be associated with one another. Familial aggregation studies allow one to further explore their relatedness. METHODS: Probands with ET (n = 110), PD (n = 130) or both ET and PD (n = 27) and control probands (n = 177) reported whether they had relatives with these diseases or with non-specific tremor. RESULTS: A greater proportion of ET probands than control probands reported relatives with ET (30.0 vs. 2.8%, p < 0.001), non-specific tremor (38.2 vs. 13.6%, p < 0.001) and both ET and PD in different relatives (6.4 vs. 0.6%, p = 0.004). A greater proportion of PD probands than control probands reported relatives with PD (20.0 vs. 8.5%, p = 0.003), ET (11.5 vs. 2.8%, p = 0.002) and both ET and PD in different relatives (6.9 vs. 0.6%, p = 0.002). CONCLUSIONS: This study provides evidence for the aggregation of ET in ET families and PD in PD families, and the familial co-aggregation of ET and PD.
BACKGROUND: Current data suggest that the 2 common tremor disorders, essential tremor (ET) and Parkinson's disease (PD), may be associated with one another. Familial aggregation studies allow one to further explore their relatedness. METHODS: Probands with ET (n = 110), PD (n = 130) or both ET and PD (n = 27) and control probands (n = 177) reported whether they had relatives with these diseases or with non-specific tremor. RESULTS: A greater proportion of ET probands than control probands reported relatives with ET (30.0 vs. 2.8%, p < 0.001), non-specific tremor (38.2 vs. 13.6%, p < 0.001) and both ET and PD in different relatives (6.4 vs. 0.6%, p = 0.004). A greater proportion of PD probands than control probands reported relatives with PD (20.0 vs. 8.5%, p = 0.003), ET (11.5 vs. 2.8%, p = 0.002) and both ET and PD in different relatives (6.9 vs. 0.6%, p = 0.002). CONCLUSIONS: This study provides evidence for the aggregation of ET in ET families and PD in PD families, and the familial co-aggregation of ET and PD.
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Authors: Monica Diez-Fairen; Gabrielle Houle; Sara Ortega-Cubero; Sara Bandres-Ciga; Ignacio Alvarez; Maria Carcel; Laura Ibañez; Maria Victoria Fernandez; John P Budde; Jean-Rémi Trotta; Raúl Tonda; Jessica X Chong; Michael J Bamshad; Deborah A Nickerson; Miquel Aguilar; Juan P Tartari; Alexandre Gironell; Elena García-Martín; Jose Ag Agundez; Hortensia Alonso-Navarro; Felix Javier Jimenez-Jimenez; Manel Fernandez; Francesc Valldeoriola; Maria Jose Marti; Eduard Tolosa; Francisco Coria; Maria A Pastor; Carles Vilariño-Güell; Alex Rajput; Patrick A Dion; Carlos Cruchaga; Guy A Rouleau; Pau Pastor Journal: Parkinsonism Relat Disord Date: 2020-11-24 Impact factor: 4.891
Authors: Isabel Alfradique-Dunham; Rami Al-Ouran; Rainer von Coelln; Cornelis Blauwendraat; Emily Hill; Lan Luo; Amanda Stillwell; Emily Young; Anita Kaw; Manuela Tan; Calwing Liao; Dena Hernandez; Lasse Pihlstrom; Donald Grosset; Lisa M Shulman; Zhandong Liu; Guy A Rouleau; Mike Nalls; Andrew B Singleton; Huw Morris; Joseph Jankovic; Joshua M Shulman Journal: Neurol Genet Date: 2021-01-28