Literature DB >> 26602908

Research in Emergency and Critical Care Settings: Debates, Obstacles and Solutions.

Ayman El-Menyar1,2,3, Mohammad Asim4, Rifat Latifi5, Hassan Al-Thani6.   

Abstract

Research is an integral part of evidence-based practice in the emergency department and critical care unit that improves patient management. It is important to understand the need and major obstacles for conducting research in emergency settings. Herein, we review the literature for the obligations, ethics and major implications of emergency research and the associated limiting factors influencing research activities in critical care and emergency settings. We reviewed research engines such as PubMed, MEDLINE, and EMBASE for the last two decades using the key words "emergency department", "critical care", "research", "consent", and "ethics" as the search terms. Research within emergency settings is slow or non-existent due to time and financial constraints as well as the lack of a research tradition. There are several barriers to conducting research studies in emergency situations such as who, what, when, and how to obtain patient consent. The emergency environment is highly pressurized, emotional, and overburdened. The time taken for research is a particular risk that could delay the desired immediate interventions. Ethical issues abound, particularly relating to informed consent. Research in emergency settings is still in its infancy. Thus, there is a strong need for extensive research in the emergency setting through community awareness, resource management, ethics, collaborations, capacity building, and the development of a research interest for the improvement of patient care and outcomes. We need to establish a well-structured plan to assess and track the decision-making capacity, consider a multistep enrolment and consent strategy, and develop an integrated approach for recruitment into studies.

Entities:  

Keywords:  Consent; Critical care; Emergency; Ethics; Research

Mesh:

Year:  2015        PMID: 26602908     DOI: 10.1007/s11948-015-9730-5

Source DB:  PubMed          Journal:  Sci Eng Ethics        ISSN: 1353-3452            Impact factor:   3.525


  54 in total

Review 1.  Access to care: a review of the emergency medicine literature.

Authors:  L D Richardson; U Hwang
Journal:  Acad Emerg Med       Date:  2001-11       Impact factor: 3.451

2.  Clinical and translational research in global health and emergency care: a research agenda.

Authors:  Michael S Runyon; Hendry R Sawe; Adam C Levine; Amelia Pousson; Darlene R House; Pooja Agrawal; Maxwell Osei-Ampofo; Scott G Weiner; Katherine Douglass
Journal:  Acad Emerg Med       Date:  2013-12       Impact factor: 3.451

3.  New European Union regulation of clinical trials is conflicting on deferred consent in emergency situations.

Authors:  Carrol Gamble; Kerry Woolfall; Paula Williamson; Richard Appleton; Bridget Young
Journal:  BMJ       Date:  2013-02-06

4.  Informed consent in clinical trials in critical care: experience from the PAC-Man Study.

Authors:  Sheila E Harvey; Diana Elbourne; Joanne Ashcroft; Carys M Jones; Kathryn Rowan
Journal:  Intensive Care Med       Date:  2006-09-21       Impact factor: 17.440

5.  Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial.

Authors:  Ian G Jacobs; Judith C Finn; George A Jelinek; Harry F Oxer; Peter L Thompson
Journal:  Resuscitation       Date:  2011-07-02       Impact factor: 5.262

Review 6.  Emergency intervention to break the cycle of drunken driving and recurrent injury.

Authors:  C Madden; T B Cole
Journal:  Ann Emerg Med       Date:  1995-08       Impact factor: 5.721

Review 7.  Confronting the ethical challenges to informed consent in emergency medicine research.

Authors:  Terri A Schmidt; David Salo; Jason A Hughes; Jean T Abbott; Joel M Geiderman; Catherine X Johnson; Katie B McClure; Mary Pat McKay; Junaid A Razzak; Raquel M Schears; Robert C Solomon
Journal:  Acad Emerg Med       Date:  2004-10       Impact factor: 3.451

8.  Informed consent, vulnerability and the risks of group-specific attribution.

Authors:  Berta M Schrems
Journal:  Nurs Ethics       Date:  2014-02-03       Impact factor: 2.874

9.  A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.

Authors:  L F Marshall; A I Maas; S B Marshall; A Bricolo; M Fearnside; F Iannotti; M R Klauber; J Lagarrigue; R Lobato; L Persson; J D Pickard; J Piek; F Servadei; G N Wellis; G F Morris; E D Means; B Musch
Journal:  J Neurosurg       Date:  1998-10       Impact factor: 5.115

10.  Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.

Authors:  Djillali Annane; Véronique Sébille; Claire Charpentier; Pierre-Edouard Bollaert; Bruno François; Jean-Michel Korach; Gilles Capellier; Yves Cohen; Elie Azoulay; Gilles Troché; Philippe Chaumet-Riffaud; Philippe Chaumet-Riffaut; Eric Bellissant
Journal:  JAMA       Date:  2002-08-21       Impact factor: 56.272

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  2 in total

1.  Factors Influencing Participation in Clinical Trials: Emergency Medicine vs. Other Specialties.

Authors:  Anita Kurt; Hope M Kincaid; Charity Curtis; Lauren Semler; Matthew Meyers; Melanie Johnson; Beth A Careyva; Brian Stello; Timothy J Friel; Mark C Knouse; John C Smulian; Jeanne L Jacoby
Journal:  West J Emerg Med       Date:  2017-07-17

2.  Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov

Authors:  Lisa Calvocoressi; Jesse Reynolds; Benjamin Johnson; Meghan M Warzoha; Megan Carroll; Federico E Vaca; Lori Post; James Dziura
Journal:  West J Emerg Med       Date:  2020-02-24
  2 in total

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