| Literature DB >> 26590417 |
Zhen Zhao1, Amy R Nelson1, Christer Betsholtz2, Berislav V Zlokovic3.
Abstract
Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.Entities:
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Year: 2015 PMID： 26590417 PMCID： PMC4655822 DOI： 10.1016/j.cell.2015.10.067
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582