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Literature DB >> 29216454

Fibrinogen in the Nervous System: Glia Beware.

Abstract

Re-myelination of CNS nerves after injury is ineffective. Here, Petersen et al. (2017) show that the blood clotting protein fibrinogen inhibits nerve repair by preventing oligodendrocyte progenitor cells from differentiating into myelinating oligodendrocytes. Targeting fibrinogen or its downstream BMP signaling pathway may help with CNS repair.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Fibrinogen

Year: 2017 PMID： 29216454 PMCID： PMC6782050 DOI： 10.1016/j.neuron.2017.11.021

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

10 in total

1. Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation.

Authors: Katerina Akassoglou; Wei Ming Yu; Pinar Akpinar; Sidney Strickland
Journal: Neuron Date: 2002-03-14 Impact factor: 17.173

Review 2. Fibrinogen signal transduction in the nervous system.

Authors: J K Ryu; D Davalos; K Akassoglou
Journal: J Thromb Haemost Date: 2009-07 Impact factor: 5.824

3. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.

Authors: T H Bugge; K W Kombrinck; M J Flick; C C Daugherty; M J Danton; J L Degen
Journal: Cell Date: 1996-11-15 Impact factor: 41.582

4. Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease.

Authors: Marta Cortes-Canteli; Justin Paul; Erin H Norris; Robert Bronstein; Hyung Jin Ahn; Daria Zamolodchikov; Shivaprasad Bhuvanendran; Katherine M Fenz; Sidney Strickland
Journal: Neuron Date: 2010-06-10 Impact factor: 17.173

Review 5. Establishment and Dysfunction of the Blood-Brain Barrier.

Authors: Zhen Zhao; Amy R Nelson; Christer Betsholtz; Berislav V Zlokovic
Journal: Cell Date: 2015-11-19 Impact factor: 41.582

6. Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

Authors: Matthew J Flick; XinLi Du; David P Witte; Markéta Jirousková; Dmitry A Soloviev; Steven J Busuttil; Edward F Plow; Jay L Degen
Journal: J Clin Invest Date: 2004-06 Impact factor: 14.808

7. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.

Authors: Katerina Akassoglou; Ryan A Adams; Jan Bauer; Peter Mercado; Vivian Tseveleki; Hans Lassmann; Lesley Probert; Sidney Strickland
Journal: Proc Natl Acad Sci U S A Date: 2004-04-19 Impact factor: 11.205

Review 8. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis.

Authors: R A Adams; C Schachtrup; D Davalos; I Tsigelny; K Akassoglou
Journal: Curr Med Chem Date: 2007 Impact factor: 4.530

9. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury.

Authors: K Akassoglou; K W Kombrinck; J L Degen; S Strickland
Journal: J Cell Biol Date: 2000-05-29 Impact factor: 10.539

10. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Authors: Mark A Petersen; Jae Kyu Ryu; Kae-Jiun Chang; Ainhoa Etxeberria; Sophia Bardehle; Andrew S Mendiola; Wanjiru Kamau-Devers; Stephen P J Fancy; Andrea Thor; Eric A Bushong; Bernat Baeza-Raja; Catriona A Syme; Michael D Wu; Pamela E Rios Coronado; Anke Meyer-Franke; Stephanie Yahn; Lauriane Pous; Jae K Lee; Christian Schachtrup; Hans Lassmann; Eric J Huang; May H Han; Martina Absinta; Daniel S Reich; Mark H Ellisman; David H Rowitch; Jonah R Chan; Katerina Akassoglou
Journal: Neuron Date: 2017-11-02 Impact factor: 17.173