Literature DB >> 26587334

Targeting STING pathways for the treatment of cancer.

Claudia Gravekamp1, Dinesh Chandra1.   

Abstract

Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

Entities:  

Keywords:  IL-12; Listeria-Mage-b; STING ligand; c-di-GMP; metastatic breast cancer

Year:  2015        PMID： 26587334      PMCID： PMC4635943          DOI： 10.4161/2162402X.2014.988463

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Cyclic diguanylic acid and cellulose synthesis in Agrobacterium tumefaciens.

Authors:  D Amikam; M Benziman
Journal:  J Bacteriol       Date:  1989-12       Impact factor: 3.490

2.  Bacterial c-di-GMP is an immunostimulatory molecule.

Authors:  David K R Karaolis; Terry K Means; De Yang; Munehisa Takahashi; Teizo Yoshimura; Eric Muraille; Dana Philpott; John T Schroeder; Mamoru Hyodo; Yoshihiro Hayakawa; Brian G Talbot; Eric Brouillette; François Malouin
Journal:  J Immunol       Date:  2007-02-15       Impact factor: 5.422

Review 3.  Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses.

Authors:  Glen N Barber
Journal:  Curr Opin Immunol       Date:  2011-01-14       Impact factor: 7.486

4.  Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Authors:  Jiaxi Wu; Lijun Sun; Xiang Chen; Fenghe Du; Heping Shi; Chuo Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

5.  STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancer.

Authors:  Dinesh Chandra; Wilber Quispe-Tintaya; Arthee Jahangir; Denise Asafu-Adjei; Ilyssa Ramos; Herman O Sintim; Jie Zhou; Yoshihiro Hayakawa; David K R Karaolis; Claudia Gravekamp
Journal:  Cancer Immunol Res       Date:  2014-06-09       Impact factor: 11.151

6.  Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.

Authors:  Mercedes B Fuertes; Aalok K Kacha; Justin Kline; Seng-Ryong Woo; David M Kranz; Kenneth M Murphy; Thomas F Gajewski
Journal:  J Exp Med       Date:  2011-09-19       Impact factor: 14.307

7.  STING is a direct innate immune sensor of cyclic di-GMP.

Authors:  Dara L Burdette; Kathryn M Monroe; Katia Sotelo-Troha; Jeff S Iwig; Barbara Eckert; Mamoru Hyodo; Yoshihiro Hayakawa; Russell E Vance
Journal:  Nature       Date:  2011-09-25       Impact factor: 49.962

8.  IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model.

Authors:  Azucena Gomez-Cabrero; Wolfgang Wrasidlo; Ralph A Reisfeld
Journal:  PLoS One       Date:  2013-08-27       Impact factor: 3.240

9.  STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

Authors:  Hiroki Ishikawa; Glen N Barber
Journal:  Nature       Date:  2008-08-24       Impact factor: 49.962

10.  Mage-b vaccine delivered by recombinant Listeria monocytogenes is highly effective against breast cancer metastases.

Authors:  S H Kim; F Castro; D Gonzalez; P C Maciag; Y Paterson; C Gravekamp
Journal:  Br J Cancer       Date:  2008-08-19       Impact factor: 7.640
  10 in total
  6 in total

Review 1.  Turbocharging vaccines: emerging adjuvants for dendritic cell based therapeutic cancer vaccines.

Authors:  Mansi Saxena; Nina Bhardwaj
Journal:  Curr Opin Immunol       Date:  2017-07-18       Impact factor: 7.486

Review 2.  Versatile modes of cellular regulation via cyclic dinucleotides.

Authors:  Petya Violinova Krasteva; Holger Sondermann
Journal:  Nat Chem Biol       Date:  2017-03-22       Impact factor: 15.040

Review 3.  Therapeutic cancer vaccines.

Authors:  Mansi Saxena; Sjoerd H van der Burg; Cornelis J M Melief; Nina Bhardwaj
Journal:  Nat Rev Cancer       Date:  2021-04-27       Impact factor: 60.716

4.  Decreased expression of STING predicts poor prognosis in patients with gastric cancer.

Authors:  Shushu Song; Peike Peng; Zhaoqing Tang; Junjie Zhao; Weicheng Wu; Haojie Li; Miaomiao Shao; Lili Li; Caiting Yang; Fangfang Duan; Mingming Zhang; Jie Zhang; Hao Wu; Can Li; Xuefei Wang; Hongshan Wang; Yuanyuan Ruan; Jianxin Gu
Journal:  Sci Rep       Date:  2017-02-08       Impact factor: 4.379

5.  Mechanisms of transcriptional activation of the stimulator of interferon genes by transcription factors CREB and c-Myc.

Authors:  Yan-Yan Wang; Rui Jin; Guo-Ping Zhou; Hua-Guo Xu
Journal:  Oncotarget       Date:  2016-12-20

Review 6.  Trial watch: STING agonists in cancer therapy.

Authors:  Julie Le Naour; Laurence Zitvogel; Lorenzo Galluzzi; Erika Vacchelli; Guido Kroemer
Journal:  Oncoimmunology       Date:  2020-06-16       Impact factor: 8.110
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.