Literature DB >> 26585534

Towards a hit for every target.

Steve Rees1, Philip Gribbon2, Karen Birmingham3, William P Janzen4, Garry Pairaudeau1.   

Abstract

Technological advances coupled with novel collaborative strategies for compound sourcing and management are poised to transform the utility of high-throughput screening.

Mesh：

Year:  2015        PMID： 26585534     DOI： 10.1038/nrd.2015.19

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  4 in total

1.  Opening the lead generation toolbox.

Authors:  Peter B Simpson; Melvin Reichman
Journal:  Nat Rev Drug Discov       Date:  2014-01       Impact factor: 84.694

Review 2.  Impact of high-throughput screening in biomedical research.

Authors:  Ricardo Macarron; Martyn N Banks; Dejan Bojanic; David J Burns; Dragan A Cirovic; Tina Garyantes; Darren V S Green; Robert P Hertzberg; William P Janzen; Jeff W Paslay; Ulrich Schopfer; G Sitta Sittampalam
Journal:  Nat Rev Drug Discov       Date:  2011-03       Impact factor: 84.694

3.  Shaping a screening file for maximal lead discovery efficiency and effectiveness: elimination of molecular redundancy.

Authors:  Gregory A Bakken; Andrew S Bell; Markus Boehm; Jeremy R Everett; Rosalia Gonzales; David Hepworth; Jacquelyn L Klug-McLeod; Jeremy Lanfear; Jens Loesel; John Mathias; Terence P Wood
Journal:  J Chem Inf Model       Date:  2012-10-31       Impact factor: 4.956

Review 4.  Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.

Authors:  David Cook; Dearg Brown; Robert Alexander; Ruth March; Paul Morgan; Gemma Satterthwaite; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2014-05-16       Impact factor: 84.694
  4 in total
  4 in total

1.  Impact of a five-dimensional framework on R&D productivity at AstraZeneca.

Authors:  Paul Morgan; Dean G Brown; Simon Lennard; Mark J Anderton; J Carl Barrett; Ulf Eriksson; Mark Fidock; Bengt Hamrén; Anthony Johnson; Ruth E March; James Matcham; Jerome Mettetal; David J Nicholls; Stefan Platz; Steve Rees; Michael A Snowden; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2018-01-19       Impact factor: 84.694

Review 2.  Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders.

Authors:  Sweta Shah; Marc Marie Dooms; Sofia Amaral-Garcia; Mariana Igoillo-Esteve
Journal:  Front Pharmacol       Date:  2021-12-21       Impact factor: 5.810

3.  A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport.

Authors:  John Vincent; Marian Preston; Elizabeth Mouchet; Nicolas Laugier; Adam Corrigan; Jérôme Boulanger; Dean G Brown; Roger Clark; Mark Wigglesworth; Andrew P Carter; Simon L Bullock
Journal:  SLAS Discov       Date:  2020-05-21       Impact factor: 3.341

4.  Fluorescence-based assay as a new screening tool for toxic chemicals.

Authors:  Ewa Moczko; Evgeny M Mirkes; César Cáceres; Alexander N Gorban; Sergey Piletsky
Journal:  Sci Rep       Date:  2016-09-22       Impact factor: 4.379
  4 in total

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