Literature DB >> 21358738

Impact of high-throughput screening in biomedical research.

Ricardo Macarron1, Martyn N Banks, Dejan Bojanic, David J Burns, Dragan A Cirovic, Tina Garyantes, Darren V S Green, Robert P Hertzberg, William P Janzen, Jeff W Paslay, Ulrich Schopfer, G Sitta Sittampalam.   

Abstract

High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.

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Year:  2011        PMID： 21358738     DOI： 10.1038/nrd3368

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  57 in total

1.  Who wants to be irrational?

Authors:  Roger Lahana
Journal:  Drug Discov Today       Date:  2003-08-01       Impact factor: 7.851

2.  Do structurally similar molecules have similar biological activity?

Authors:  Yvonne C Martin; James L Kofron; Linda M Traphagen
Journal:  J Med Chem       Date:  2002-09-12       Impact factor: 7.446

Review 3.  Enhancements of screening collections to address areas of unmet medical need: an industry perspective.

Authors:  David H Drewry; Ricardo Macarron
Journal:  Curr Opin Chem Biol       Date:  2010-04-21       Impact factor: 8.822

4.  Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells.

Authors:  Priya Kunapuli; Wei Zheng; Michael Weber; Kelli Solly; Rebecca Mull; Michael Platchek; Mei Cong; Zhong Zhong; Berta Strulovici
Journal:  Assay Drug Dev Technol       Date:  2005-02       Impact factor: 1.738

5.  Drug discovery in jeopardy.

Authors:  Pedro Cuatrecasas
Journal:  J Clin Invest       Date:  2006-11       Impact factor: 14.808

Review 6.  Cryopreserved cells facilitate cell-based drug discovery.

Authors:  Guido J R Zaman; Jeroen A D M de Roos; Marion Blomenröhr; Chris J van Koppen; Julia Oosterom
Journal:  Drug Discov Today       Date:  2007-06-27       Impact factor: 7.851

7.  An efficient method for the detection and elimination of systematic error in high-throughput screening.

Authors:  Vladimir Makarenkov; Pablo Zentilli; Dmytro Kevorkov; Andrei Gagarin; Nathalie Malo; Robert Nadon
Journal:  Bioinformatics       Date:  2007-04-26       Impact factor: 6.937

Review 8.  Lessons from 60 years of pharmaceutical innovation.

Authors:  Bernard Munos
Journal:  Nat Rev Drug Discov       Date:  2009-12       Impact factor: 84.694

9.  The A, B, Cs of G-protein-coupled receptor pharmacology in assay development for HTS.

Authors:  Dj McLoughlin; F Bertelli; C Williams
Journal:  Expert Opin Drug Discov       Date:  2007-05       Impact factor: 6.098

Review 10.  From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Authors:  Bart L De Corte
Journal:  J Med Chem       Date:  2005-03-24       Impact factor: 7.446
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  266 in total

Review 1.  High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.

Authors:  Agnieszka B Bialkowska; Vincent W Yang
Journal:  Future Oncol       Date:  2012-03       Impact factor: 3.404

Review 2.  Finding the sweet spot: the role of nature and nurture in medicinal chemistry.

Authors:  Michael M Hann; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2012-04-30       Impact factor: 84.694

Review 3.  Diagnosing the decline in pharmaceutical R&D efficiency.

Authors:  Jack W Scannell; Alex Blanckley; Helen Boldon; Brian Warrington
Journal:  Nat Rev Drug Discov       Date:  2012-03-01       Impact factor: 84.694

Review 4.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

5.  Towards a hit for every target.

Authors:  Steve Rees; Philip Gribbon; Karen Birmingham; William P Janzen; Garry Pairaudeau
Journal:  Nat Rev Drug Discov       Date:  2015-11-20       Impact factor: 84.694

6.  Dark chemical matter as a promising starting point for drug lead discovery.

Authors:  Anne Mai Wassermann; Eugen Lounkine; Dominic Hoepfner; Gaelle Le Goff; Frederick J King; Christian Studer; John M Peltier; Melissa L Grippo; Vivian Prindle; Jianshi Tao; Ansgar Schuffenhauer; Iain M Wallace; Shanni Chen; Philipp Krastel; Amanda Cobos-Correa; Christian N Parker; John W Davies; Meir Glick
Journal:  Nat Chem Biol       Date:  2015-10-19       Impact factor: 15.040

7.  Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana.

Authors:  B K Amos; Victoria G Pook; Seth Debolt
Journal:  J Vis Exp       Date:  2018-04-30       Impact factor: 1.355

8.  Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy.

Authors:  Pedro M Valencia; Eric M Pridgen; Minsoung Rhee; Robert Langer; Omid C Farokhzad; Rohit Karnik
Journal:  ACS Nano       Date:  2013-11-11       Impact factor: 15.881

9.  FINDSITEcomb2.0: A New Approach for Virtual Ligand Screening of Proteins and Virtual Target Screening of Biomolecules.

Authors:  Hongyi Zhou; Hongnan Cao; Jeffrey Skolnick
Journal:  J Chem Inf Model       Date:  2018-10-16       Impact factor: 4.956

Review 10.  Antimalarial drug discovery - approaches and progress towards new medicines.

Authors:  Erika L Flannery; Arnab K Chatterjee; Elizabeth A Winzeler
Journal:  Nat Rev Microbiol       Date:  2013-11-11       Impact factor: 60.633
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