| Literature DB >> 26584879 |
Constantinos G Neochoritis1, Kan Wang, Natalia Estrada-Ortiz, Eberhardt Herdtweck, Katarzyna Kubica, Aleksandra Twarda, Krzysztof M Zak, Tad A Holak, Alexander Dömling.
Abstract
The protein–protein interaction of p53 and MDM2/X is a promising non genotoxic anticancer target. A rapid and efficient methodology was developed to synthesize the 2,30-bis(10H-indole) heterocyclic scaffold 2 as ester, acid and amide derivatives. Their binding affinity with MDM2 was evaluated using both fluorescence polarization (FP) assay and HSQC experiments, indicating good inhibition and a perfect starting point for further optimizations.Entities:
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Year: 2015 PMID： 26584879 PMCID： PMC4764400 DOI： 10.1016/j.bmcl.2015.11.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823