Literature DB >> 26573594

Older adults with difficulty swallowing oral medicines: a systematic review of the literature.

Aoife Mc Gillicuddy1, Abina M Crean2, Laura J Sahm3,4.   

Abstract

PURPOSE: Difficulty swallowing oral medicines may arise due to swallowing disorders or due to patient self-reported difficulty in the absence of objective evidence of swallowing dysfunction. Medication use increases with age; therefore, difficulty swallowing medication may complicate medicine administration to older patients. Modifying oral medicines can impact on the safety, quality and efficacy of the medication. The objective of this systematic review is to critically appraise the evidence regarding the prevalence of difficulty swallowing oral medicines and the modification of oral medicines to overcome swallowing difficulties in the older cohort.
METHODS: A systematic search of PubMed, EMBASE, MEDLINE, CINAHL, Scopus, Web of Science, The Cochrane Library, PsycINFO and ProQuest databases was conducted from database inception to November 2014. Studies investigating the prevalence of difficulty swallowing oral medicines or the modification of oral medicines were eligible for inclusion. A narrative analysis of the results was conducted.
RESULTS: Five studies met the inclusion criteria. The results suggest that approximately 14 % of community-dwelling older patients experience difficulty swallowing medicines. Between one quarter and one third of occasions of medicine administration to older patients involve the modification of oral medicines.
CONCLUSIONS: Difficulty swallowing oral medicines and the modification of medicines are reported as being common issues in the older cohort. However, evidence to support such contentions is limited. Future research should investigate the prevalence of medicine modification for older patients in all settings and identify what medicines are modified. This will allow targeting of interventions to optimise medicine administration to older patients.

Entities:  

Keywords:  Dysphagia; Medicine manipulation; Older person; Oral administration; Systematic review

Mesh:

Substances:

Year:  2015        PMID: 26573594     DOI: 10.1007/s00228-015-1979-8

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN: 0031-6970            Impact factor:   2.953


  53 in total

1.  Dysphagia in a general practice population.

Authors:  Heather Morris
Journal:  Nurs Older People       Date:  2005-11

2.  "Avoid the crush": hazards of medication administration in patients with dysphagia or a feeding tube.

Authors:  Patricia Cornish
Journal:  CMAJ       Date:  2005-03-29       Impact factor: 8.262

Review 3.  A meta-analysis of the association between adherence to drug therapy and mortality.

Authors:  Scot H Simpson; Dean T Eurich; Sumit R Majumdar; Rajdeep S Padwal; Ross T Tsuyuki; Janice Varney; Jeffrey A Johnson
Journal:  BMJ       Date:  2006-06-21

4.  Effect of liquid bolus consistency and delivery method on aspiration and pharyngeal retention in dysphagia patients.

Authors:  K V Kuhlemeier; J B Palmer; D Rosenberg
Journal:  Dysphagia       Date:  2001       Impact factor: 3.438

Review 5.  Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy.

Authors:  S Stegemann; M Gosch; J Breitkreutz
Journal:  Int J Pharm       Date:  2012-04-15       Impact factor: 5.875

6.  Crushed clopidogrel administered via nasogastric tube has faster and greater absorption than oral whole tablets.

Authors:  M Urooj Zafar; Michael E Farkouh; Valentin Fuster; James H Chesebro
Journal:  J Interv Cardiol       Date:  2009-05-28       Impact factor: 2.279

7.  Omission of dysphagia therapies in hospital discharge communications.

Authors:  Amy Kind; Paul Anderson; Jacqueline Hind; JoAnne Robbins; Maureen Smith
Journal:  Dysphagia       Date:  2010-01-23       Impact factor: 3.438

8.  A qualitative study of the problems surrounding medicine administration to patients with dysphagia.

Authors:  Jennifer Kelly; Gibson D'Cruz; David Wright
Journal:  Dysphagia       Date:  2008-08-08       Impact factor: 3.438

9.  Stability and compatibility of tegaserod from crushed tablets mixed in beverages and foods.

Authors:  Marie-Noëlle Carrier; Olivier Garinot; Christian Vitzling
Journal:  Am J Health Syst Pharm       Date:  2004-06-01       Impact factor: 2.637

10.  Use of thickened liquids in skilled nursing facilities.

Authors:  Victoria H Castellanos; Ellen Butler; Lynda Gluch; Brigitte Burke
Journal:  J Am Diet Assoc       Date:  2004-08
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  7 in total

Review 1.  Solid Oral Dosage Forms Use in Adults with Neurological Disorders and Swallowing Difficulties: A Scoping Review.

Authors:  Carolina Justus Buhrer Ferreira-Neto; Rayza Assis de Andrade; Fernanda Stumpf Tonin; Astrid Wiens
Journal:  Dysphagia       Date:  2021-10-15       Impact factor: 2.733

2.  Combining Liquid Oral Drugs with Thickener: Compatibility and Changes in Viscosity.

Authors:  Patricia Bravo-José; Carmen Sáez-LLeó; Elena Moreno-Guillamont
Journal:  Dysphagia       Date:  2021-08-09       Impact factor: 2.733

3.  Oral medicine modification for older adults: a qualitative study of nurses.

Authors:  Aoife Mc Gillicuddy; Abina M Crean; Maria Kelly; Laura Sahm
Journal:  BMJ Open       Date:  2017-12-14       Impact factor: 2.692

4.  Validation of the PILL-5: A 5-Item Patient Reported Outcome Measure for Pill Dysphagia.

Authors:  Nogah Nativ-Zeltzer; Ahmed Bayoumi; Van Pierre Mandin; Matthew Kaufman; Indulaxmi Seeni; Maggie A Kuhn; Peter C Belafsky
Journal:  Front Surg       Date:  2019-07-24

5.  Performance of Tablet Splitters, Crushers, and Grinders in Relation to Personalised Medication with Tablets.

Authors:  Herman J Woerdenbag; J Carolina Visser; Marlyn P A M Leferink Op Reinink; Roël R van Orsoy; Anko C Eissens; Paul Hagedoorn; Hilda Dijkstra; Derk P Allersma; Shi W Ng; Oscar S N M Smeets; Henderik W Frijlink
Journal:  Pharmaceutics       Date:  2022-01-28       Impact factor: 6.321

Review 6.  A spoonful of sugar helps the medicine go down? A review of strategies for making pills easier to swallow.

Authors:  Aida Sefidani Forough; Esther Tl Lau; Kathryn J Steadman; Julie Ay Cichero; Greg J Kyle; Jose Manuel Serrano Santos; Lisa M Nissen
Journal:  Patient Prefer Adherence       Date:  2018-07-26       Impact factor: 2.711

7.  Pharmacokinetics and Use-Testing of Apalutamide Prepared in Aqueous Food Vehicles for Alternative Administration.

Authors:  Alex Yu; Maura Erba; Anasuya Hazra
Journal:  Clin Pharmacol Drug Dev       Date:  2021-07-17
  7 in total

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