Literature DB >> 26569161

Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance.

Else K Hoffmann1, Belinda H Sørensen1, Daniel P R Sauter1, Ian H Lambert1.   

Abstract

Volume-regulated channels for anions (VRAC) / organic osmolytes (VSOAC) play essential roles in cell volume regulation and other cellular functions, e.g. proliferation, cell migration and apoptosis. LRRC8A, which belongs to the leucine rich-repeat containing protein family, was recently shown to be an essential component of both VRAC and VSOAC. Reduced VRAC and VSOAC activities are seen in drug resistant cancer cells. ANO1 is a calcium-activated chloride channel expressed on the plasma membrane of e.g., secretory epithelia. ANO1 is amplified and highly expressed in a large number of carcinomas. The gene, encoding for ANO1, maps to a region on chromosome 11 (11q13) that is frequently amplified in cancer cells. Knockdown of ANO1 impairs cell proliferation and cell migration in several cancer cells. Below we summarize the basic biophysical properties of VRAC, VSOAC and ANO1 and their most important cellular functions as well as their role in cancer and drug resistance.

Entities:  

Keywords:  LRRC8A; TMEM16A; VRAC; VSOAC; anoctamins; apoptotic volume decrease; regulatory volume decrease

Mesh：

Substances：

Year:  2015        PMID： 26569161      PMCID： PMC4850047          DOI： 10.1080/19336950.2015.1089007

Source DB:  PubMed          Journal:  Channels (Austin)        ISSN： 1933-6950            Impact factor:   2.581


  160 in total

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Journal:  J Physiol       Date:  1979-11       Impact factor: 5.182

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Authors:  David M Browe; Clive M Baumgarten
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5.  Flow fluorometry quantification of anion channel VRAC subunit LRRC8A at the membrane of living U937 cells.

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Review 7.  Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery.

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9.  A Tool for Computation of Changes in Na+, K+, Cl- Channels and Transporters Due to Apoptosis by Data on Cell Ion and Water Content Alteration.

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