Literature DB >> 31279157

The multifaceted role of TMEM16A in cancer.

David Crottès1, Lily Yeh Jan2.   

Abstract

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over decades, TMEM16A over-expression and contribution to prognosis have been widely studied for multiple cancers strengthening the idea that TMEM16A could be a valuable biomarker and a promising therapeutic target. Surprisingly, from the survey of the literature, it appears that TMEM16A has been involved in multiple cancer-related functions and a large number of molecular targets of TMEM16A have been proposed. Thus, TMEM16A appears to be an ion channel with a multifaceted role in cancers. In this review, we summarize the latest development regarding TMEM16A contribution to cancers. We will survey TMEM16A contribution in cancer prognosis, the origins of its over-expression in cancer cells, the multiple biological functions and molecular pathways regulated by TMEM16A. Then, we will consider the question regarding the molecular mechanism of TMEM16A in cancers and the possible basis for the multifaceted role of TMEM16A in cancers.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anoctamin-1; Calcium-activated chloride channels; Cancer; TMEM16A

Year:  2019        PMID： 31279157      PMCID： PMC6711484          DOI： 10.1016/j.ceca.2019.06.004

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  132 in total

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Journal:  Science       Date:  2008-09-04       Impact factor: 47.728

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8.  Pancreatic expression of DOG1: a novel gastrointestinal stromal tumor (GIST) biomarker.

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  32 in total

Review 1.  Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate.

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4.  An outer-pore gate modulates the pharmacology of the TMEM16A channel.

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Journal:  Proc Natl Acad Sci U S A       Date:  2021-08-24       Impact factor: 12.779

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6.  Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.

Authors:  Son C Le; Huanghe Yang
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 3.650

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Review 10.  The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

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Journal:  Acta Pharm Sin B       Date:  2020-12-09       Impact factor: 11.413
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