Diego Cantor-Rivera1,2, John S H Baxter3,4, Sandrine de Ribaupierrre3,4,5,6, Jonathan C Lau6, Seyed M Mirsattari5,6, Maged Goubran3,4, Jorge G Burneo6, David A Steven6, Terry M Peters3,4,5, Ali R Khan3,5. 1. Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada. dcantor@robarts.ca. 2. Biomedical Engineering Graduate Program, Western University, London, ON, Canada. dcantor@robarts.ca. 3. Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada. 4. Biomedical Engineering Graduate Program, Western University, London, ON, Canada. 5. Department of Medical Biophysics, Western University, London, ON, Canada. 6. Epilepsy Program, Department of Clinical Neurological Sciences, Western University - London Health Science Centre, London, ON, Canada.
Abstract
PURPOSE: MRI-based diagnosis of temporal lobe epilepsy (TLE) can be challenging when pathology is not visually evident due to low image contrast or small lesion size. Computer-assisted analyses are able to detect lesions common in a specific patient population, but most techniques do not address clinically relevant individual pathologies resulting from the heterogeneous etiology of the disease. We propose a novel method to supplement the radiological inspection of TLE patients (n = 15) providing patient-specific quantitative assessment. METHOD: Regions of interest are defined across the brain and volume, relaxometry, and diffusion features are extracted from them. Statistical comparisons between individual patients and a healthy control group (n = 17) are performed on these features, identifying and visualizing significant differences through individual feature maps. Four maps are created per patient showing differences in intensity, asymmetry, and volume. RESULTS: Detailed reports were generated per patient. Abnormal hippocampal intensity and volume differences were detected in all patients diagnosed with mesial temporal sclerosis (MTS). Abnormal intensities in the temporal cortex were identified in patients with no MTS. A laterality score correctly distinguished left from right TLE in 12 out of 15 patients. CONCLUSION: The proposed focus on subject-specific quantitative changes has the potential of improving the assessment of TLE patients using MRI techniques, possibly even redefining current imaging protocols for TLE.
PURPOSE: MRI-based diagnosis of temporal lobe epilepsy (TLE) can be challenging when pathology is not visually evident due to low image contrast or small lesion size. Computer-assisted analyses are able to detect lesions common in a specific patient population, but most techniques do not address clinically relevant individual pathologies resulting from the heterogeneous etiology of the disease. We propose a novel method to supplement the radiological inspection of TLEpatients (n = 15) providing patient-specific quantitative assessment. METHOD: Regions of interest are defined across the brain and volume, relaxometry, and diffusion features are extracted from them. Statistical comparisons between individual patients and a healthy control group (n = 17) are performed on these features, identifying and visualizing significant differences through individual feature maps. Four maps are created per patient showing differences in intensity, asymmetry, and volume. RESULTS: Detailed reports were generated per patient. Abnormal hippocampal intensity and volume differences were detected in all patients diagnosed with mesial temporal sclerosis (MTS). Abnormal intensities in the temporal cortex were identified in patients with no MTS. A laterality score correctly distinguished left from right TLE in 12 out of 15 patients. CONCLUSION: The proposed focus on subject-specific quantitative changes has the potential of improving the assessment of TLEpatients using MRI techniques, possibly even redefining current imaging protocols for TLE.
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