Literature DB >> 265591

Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J.

K Shinohara, P A Cerutti.   

Abstract

The formation and excision of benzo[a]pyrene-deoxyguanosine adducts in metabolizing baby hamster kidney cells (21/C13) and secondary mouse embryo fibroblasts (C57BL/6J) was investigated. Both diastereomeric adducts, N2-(10-(7beta,8alpha,9alpha-trihydroxy-7, 8, 9, 10 tetrahydrobenzo[a]-7,8,9,10-tetrahydrobenzo[a]pyrene)yl)deoxyguanosine, were detected in both cell lines and both cell lines were capable of excising these lesions, albeit with low efficiency.

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Year:  1977        PMID： 265591      PMCID： PMC430554          DOI： 10.1073/pnas.74.3.979

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  Comparison of the cellular DNA-bound products of benzo(alpha)pyrene with the products formed by the reaction of benzo(alpha)pyrene-4,5-oxide with DNA.

Authors:  W M Baird; R G Harvey; P Brookes
Journal:  Cancer Res       Date:  1975-01       Impact factor: 12.701

Review 2.  Excision repair of DNA base damage.

Authors:  P A Cerutti
Journal:  Life Sci       Date:  1974-11-01       Impact factor: 5.037

3.  DNA excision-repair deficiency of human peripheral blood lymphocytes treated with chemical carcinogens.

Authors:  D Scudiero; A Norin; P Karran; B Strauss
Journal:  Cancer Res       Date:  1976-04       Impact factor: 12.701

4.  Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.

Authors:  I B Weinstein; A M Jeffrey; K W Jennette; S H Blobstein; R G Harvey; C Harris; H Autrup; H Kasai; K Nakanishi
Journal:  Science       Date:  1976-08-13       Impact factor: 47.728

5.  In vitro reaction of radioactive 7beta, 8alpha, --dihydroxy--9alpha, 10alpha-epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene and 7beta,8alpha--dihydroxy--9beta, 10beta--epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene with DNA.

Authors:  J Remsen; D Jerina; H Yagi; P Cerutti
Journal:  Biochem Biophys Res Commun       Date:  1977-02-07       Impact factor: 3.575

6.  Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Authors:  M Koreeda; P D Moore; H Yagi; H J Yeh; D M Jerina
Journal:  J Am Chem Soc       Date:  1976-10-13       Impact factor: 15.419

7.  Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

Authors:  A W Wood; P G Wislocki; R L Chang; W Levin; A Y Lu; J Yagi; O Hernandez; D M Herina; A H Conney
Journal:  Cancer Res       Date:  1976-09       Impact factor: 12.701

Review 8.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

Authors:  J McCann; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

9.  Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

Authors:  D R Thakker; H Yagi; A Y Lu; W Levin; A H Conney
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

10.  (+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.

Authors:  H W King; M R Osborne; F A Beland; R G Harvey; P Brookes
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205
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  10 in total

Review 1.  [The role of enzymatic DNA repair in carcinogenesis and cancer chemotherapy].

Authors:  E Harbers
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978-08-24

2.  Mechanism of reaction of carcinogen N-acetoxy-2-acetylaminofluorene with DNA.

Authors:  A M Bobst; T V Wang; P A Cerutti
Journal:  Experientia       Date:  1981-06

3.  Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines.

Authors:  W J Bodell; B Singer; G H Thomas; J E Cleaver
Journal:  Nucleic Acids Res       Date:  1979-06-25       Impact factor: 16.971

4.  Inhibition of DNA synthesis by an electrophilic metabolite of benzo[a]pyrene.

Authors:  D L Busbee; C O Joe; J O Norman; P W Rankin
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

5.  The influence of chromatin structure on the distribution of DNA repair synthesis studied by nuclease digestion.

Authors:  W J Bodell; M R Banerjee
Journal:  Nucleic Acids Res       Date:  1979-01       Impact factor: 16.971

6.  Metabolism of benzo[a]pyrene by human mammary epithelial cells: toxicity and DNA adduct formation.

Authors:  M R Stampfer; J C Bartholomew; H S Smith; J C Bartley
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

Review 7.  Differentiation of the mammary gland and susceptibility to carcinogenesis.

Authors:  J Russo; L K Tay; I H Russo
Journal:  Breast Cancer Res Treat       Date:  1982       Impact factor: 4.872

Review 8.  Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens.

Authors: 
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

9.  Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies.

Authors:  R M Santella; L L Hsieh; C D Lin; S Viet; I B Weinstein
Journal:  Environ Health Perspect       Date:  1985-10       Impact factor: 9.031

Review 10.  Molecular and cellular basis of the mammary gland susceptibility to carcinogenesis.

Authors:  J Russo; L K Tay; D R Ciocca; I H Russo
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031
  10 in total

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