Literature DB >> 959820

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.

I B Weinstein, A M Jeffrey, K W Jennette, S H Blobstein, R G Harvey, C Harris, H Autrup, H Kasai, K Nakanishi.   

Abstract

Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.

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Year:  1976        PMID： 959820     DOI： 10.1126/science.959820

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  69 in total

1.  Dnmt3a-CD is less susceptible to bulky benzo[a]pyrene diol epoxide-derived DNA lesions than prokaryotic DNA methyltransferases.

Authors:  Olga V Lukashevich; Vladimir B Baskunov; Maria V Darii; Alexander Kolbanovskiy; Alexander A Baykov; Elizaveta S Gromova
Journal:  Biochemistry       Date:  2011-01-13       Impact factor: 3.162

Review 2.  Polycyclic aromatic hydrocarbon-DNA adduct formation in prostate carcinogenesis.

Authors:  Benjamin A Rybicki; Nora L Nock; Adnan T Savera; Deliang Tang; Andrew Rundle
Journal:  Cancer Lett       Date:  2005-09-09       Impact factor: 8.679

3.  Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes.

Authors:  P Keohavong; W G Thilly
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

4.  Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions.

Authors:  E Eisenstadt; A J Warren; J Porter; D Atkins; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

5.  Hydrolysis of benzo[a]pyrene diol epoxide and its covalent binding to DNA proceed through similar rate-determining steps.

Authors:  T Meehan; D M Bond
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

6.  Metabolic activations of polycyclic hydrocarbons. Structure-activity relationships.

Authors:  R E Lehr; D M Jerina
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

7.  Covalent binding of BP-metabolites to DNA of cultured human hair follicle keratinocytes.

Authors:  M W Hukkelhoven; A M Bronkhorst; A J Vermorken
Journal:  Arch Toxicol       Date:  1985-04       Impact factor: 5.153

8.  Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids.

Authors:  A R Wolfe; J Yamamoto; T Meehan
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

9.  The molecular electrostatic potential of the B-DNA helix. VI. The regions of the base pairs in poly (dG.dC) and poly (dA.dT).

Authors:  B Pullman; D Perahia; D Cauchy
Journal:  Nucleic Acids Res       Date:  1979-08-24       Impact factor: 16.971

10.  Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: a correlation with family histories of cancer.

Authors:  T L McLemore; R R Martin; R R Springer; N Wray; E T Cantrell; D L Busbee
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890
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