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Literature DB >> 26554545

Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion.

Adam M Behrens¹, Nora G Lee², Brendan J Casey³, Priya Srinivasan², Michael J Sikorski¹, John L Daristotle¹, Anthony D Sandler², Peter Kofinas¹.

Abstract

The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.

Entities: Chemical Disease Species

Keywords: biodegradable polymers; solution blow spinning; surgical sealants; temperature responsive

Mesh：

Substances：

Year: 2015 PMID： 26554545 PMCID： PMC4961426 DOI： 10.1002/adma.201503691

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

39 in total

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13 in total

1. Spray Delivery of Intestinal Organoids to Reconstitute Epithelium on Decellularized Native Extracellular Matrix.

Authors: Dana M Schwartz; Meryem O Pehlivaner Kara; Allan M Goldstein; Harald C Ott; Adam K Ekenseair
Journal: Tissue Eng Part C Methods Date: 2017-09 Impact factor: 3.056

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3. Improving the adhesion, flexibility, and hemostatic efficacy of a sprayable polymer blend surgical sealant by incorporating silica particles.

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Journal: Acta Biomater Date: 2019-04-04 Impact factor: 8.947

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