| Literature DB >> 26551074 |
Bingbing Wan1,2, Ting Tang1,2,3, Heather Upton4, Jin Shuai1,2, Yuanzhe Zhou5, Song Li1,2, Juan Chen1,2, Joseph S Brunzelle6, Zhixiong Zeng5, Kathleen Collins4, Jian Wu1,2, Ming Lei1,2.
Abstract
Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.Entities:
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Year: 2015 PMID： 26551074 PMCID： PMC4765348 DOI： 10.1038/nsmb.3126
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369