Literature DB >> 28732250

Structural biology of telomerase and its interaction at telomeres.

Yaqiang Wang1, Juli Feigon2.   

Abstract

Telomerase is an RNP that synthesizes the 3' ends of linear chromosomes and is an important regulator of telomere length. It contains a single long non-coding telomerase RNA (TER), telomerase reverse transcriptase (TERT), and other proteins that vary among organisms. Recent progress in structural biology of telomerase includes reports of the first cryo-electron microscopy structure of telomerase, from Tetrahymena, new crystal structures of TERT domains, telomerase RNA structures and models, and identification in Tetrahymena telomerase holoenzyme of human homologues of telomere-associated proteins that have provided a more unified view of telomerase interaction at telomeres as well as insights into the role of telomerase RNA in activity and assembly.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28732250      PMCID： PMC5564310          DOI： 10.1016/j.sbi.2017.06.010

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  80 in total

1.  Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.

Authors:  Jie Fan; Nikola P Pavletich
Journal:  Genes Dev       Date:  2012-10-15       Impact factor: 11.361

2.  Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.

Authors:  Bruno Lemieux; Nancy Laterreur; Anna Perederina; Jean-François Noël; Marie-Line Dubois; Andrey S Krasilnikov; Raymund J Wellinger
Journal:  Cell       Date:  2016-05-05       Impact factor: 41.582

3.  Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human.

Authors:  Yaqiang Wang; Joseph D Yesselman; Qi Zhang; Mijeong Kang; Juli Feigon
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-16       Impact factor: 11.205

4.  Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.

Authors:  Ming Lei; Elaine R Podell; Thomas R Cech
Journal:  Nat Struct Mol Biol       Date:  2004-11-21       Impact factor: 15.369

5.  Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo.

Authors:  Darian D Cash; Osnat Cohen-Zontag; Nak-Kyoon Kim; Kinneret Shefer; Yogev Brown; Nikolai B Ulyanov; Yehuda Tzfati; Juli Feigon
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-17       Impact factor: 11.205

Review 6.  Molecular basis of telomere dysfunction in human genetic diseases.

Authors:  Grzegorz Sarek; Paulina Marzec; Pol Margalef; Simon J Boulton
Journal:  Nat Struct Mol Biol       Date:  2015-11       Impact factor: 15.369

7.  The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.

Authors:  Benjamin M Akiyama; Joseph W Parks; Michael D Stone
Journal:  Nucleic Acids Res       Date:  2015-05-04       Impact factor: 16.971

8.  The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.

Authors:  Neal F Lue; Jamie Chan; Woodring E Wright; Jerard Hurwitz
Journal:  Nat Commun       Date:  2014-12-12       Impact factor: 14.919

9.  TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.

Authors:  Franklin L Zhong; Luis F Z Batista; Adam Freund; Matthew F Pech; Andrew S Venteicher; Steven E Artandi
Journal:  Cell       Date:  2012-08-03       Impact factor: 66.850

10.  Structure of active dimeric human telomerase.

Authors:  Anselm Sauerwald; Sara Sandin; Gaël Cristofari; Sjors H W Scheres; Joachim Lingner; Daniela Rhodes
Journal:  Nat Struct Mol Biol       Date:  2013-03-10       Impact factor: 15.369
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  8 in total

1.  The non-canonical functions of telomerase reverse transcriptase gene GlTert on regulating fungal growth, oxidative stress, and ganoderic acid biosynthesis in Ganoderma lucidum.

Authors:  Guang Zhang; Chaohui Zhang; Doudou Leng; Peng Yan; Zhenhe Wang; Mingxia Zhang; Zhongwei Wu
Journal:  Appl Microbiol Biotechnol       Date:  2021-09-13       Impact factor: 5.560

Review 2.  Single-Run Catalysis and Kinetic Control of Human Telomerase Holoenzyme.

Authors:  Qiu-Xing Jiang
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

3.  Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.

Authors:  Ritwika Basu; Catherine D Eichhorn; Ryan Cheng; Robert D Peterson; Juli Feigon
Journal:  RNA Biol       Date:  2020-11-01       Impact factor: 4.652

4.  Association of telomere length and telomerase methylation with n-3 fatty acids in preschool children with obesity.

Authors:  Xuanyi Liu; Xiaozhou Liu; Qiaoyu Shi; Xiuqin Fan; Kemin Qi
Journal:  BMC Pediatr       Date:  2021-01-07       Impact factor: 2.125

5.  Associations of Maternal Polyunsaturated Fatty Acids With Telomere Length in the Cord Blood and Placenta in Chinese Population.

Authors:  Xuanyi Liu; Qiaoyu Shi; Xiuqin Fan; Hang Chen; Na Chen; Yurong Zhao; Kemin Qi
Journal:  Front Nutr       Date:  2022-01-28

6.  How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle.

Authors:  Samantha L Sanford; Griffin A Welfer; Bret D Freudenthal; Patricia L Opresko
Journal:  DNA Repair (Amst)       Date:  2021-07-31

7.  Evolutionary rates of mammalian telomere-stability genes correlate with karyotype features and female germline expression.

Authors:  Chiara Pontremoli; Diego Forni; Rachele Cagliani; Uberto Pozzoli; Mario Clerici; Manuela Sironi
Journal:  Nucleic Acids Res       Date:  2018-08-21       Impact factor: 16.971

Review 8.  Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.

Authors:  Mohd Amir; Parvez Khan; Aarfa Queen; Ravins Dohare; Mohamed F Alajmi; Afzal Hussain; Asimul Islam; Faizan Ahmad; Imtaiyaz Hassan
Journal:  Cells       Date:  2020-02-04       Impact factor: 7.666
  8 in total

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