Literature DB >> 26539561

New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond.

Megan Keniry1, Robert K Dearth1, Michael Persans1, Ramon Parsons2.   

Abstract

The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPβ and FOXO1 activated genes and signal transduction.

Entities:  

Keywords:  CEBPβ; Cancer; Immunology; Metabolism; NFIL3

Year:  2014        PMID： 26539561      PMCID： PMC4629104          DOI： 10.15190/d.2014.7

Source DB:  PubMed          Journal:  Discoveries (Craiova)        ISSN： 2359-7232


  78 in total

1.  Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.

Authors:  Philipp A Lang; Karl S Lang; Haifeng C Xu; Melanie Grusdat; Ian A Parish; Mike Recher; Alisha R Elford; Salim Dhanji; Namir Shaabani; Charles W Tran; Dilan Dissanayake; Ramtin Rahbar; Magar Ghazarian; Anne Brüstle; Jason Fine; Peter Chen; Casey T Weaver; Christoph Klose; Andreas Diefenbach; Dieter Häussinger; James R Carlyle; Susan M Kaech; Tak W Mak; Pamela S Ohashi
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-13       Impact factor: 11.205

Review 2.  Coordination of circadian timing in mammals.

Authors:  Steven M Reppert; David R Weaver
Journal:  Nature       Date:  2002-08-29       Impact factor: 49.962

3.  The role of Nfil3 in zebrafish hematopoiesis.

Authors:  Fränze Progatzky; Harriet Taylor; Laurence Bugeon; Sorcha Cassidy; Andreas Radbruch; Margaret J Dallman; Jonathan R Lamb
Journal:  Dev Comp Immunol       Date:  2012-05-02       Impact factor: 3.636

4.  The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.

Authors:  Yasutaka Motomura; Hiroshi Kitamura; Atsushi Hijikata; Yuko Matsunaga; Koichiro Matsumoto; Hiromasa Inoue; Koji Atarashi; Shohei Hori; Hiroshi Watarai; Jinfang Zhu; Masaru Taniguchi; Masato Kubo
Journal:  Nat Immunol       Date:  2011-04-03       Impact factor: 25.606

Review 5.  The transcriptional regulator NFIL3 controls IgE production.

Authors:  Paul B Rothman
Journal:  Trans Am Clin Climatol Assoc       Date:  2010

6.  Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein.

Authors:  Xin Tong; Deqiang Zhang; Katie Buelow; Anirvan Guha; Blake Arthurs; Hugh J M Brady; Lei Yin
Journal:  J Biol Chem       Date:  2013-01-02       Impact factor: 5.157

7.  The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity.

Authors:  Claudia P Coomans; Sjoerd A A van den Berg; Eliane A Lucassen; Thijs Houben; Amanda C M Pronk; Rianne D van der Spek; Andries Kalsbeek; Nienke R Biermasz; Ko Willems van Dijk; Johannes A Romijn; Johanna H Meijer
Journal:  Diabetes       Date:  2012-12-28       Impact factor: 9.461

8.  Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption.

Authors:  Jana Husse; Sophie Charlotte Hintze; Gregor Eichele; Hendrik Lehnert; Henrik Oster
Journal:  PLoS One       Date:  2012-12-28       Impact factor: 3.240

9.  Analysis of gene regulatory networks in the mammalian circadian rhythm.

Authors:  Jun Yan; Haifang Wang; Yuting Liu; Chunxuan Shao
Journal:  PLoS Comput Biol       Date:  2008-10-10       Impact factor: 4.475

10.  FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Authors:  Angie L Bookout; Marleen H M de Groot; Bryn M Owen; Syann Lee; Laurent Gautron; Heather L Lawrence; Xunshan Ding; Joel K Elmquist; Joseph S Takahashi; David J Mangelsdorf; Steven A Kliewer
Journal:  Nat Med       Date:  2013-08-11       Impact factor: 53.440
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  12 in total

1.  A wrinkle in time: circadian biology in pulmonary vascular health and disease.

Authors:  Andrew J Bryant; Elnaz Ebrahimi; Amy Nguyen; Christopher A Wolff; Michelle L Gumz; Andrew C Liu; Karyn A Esser
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2021-12-01       Impact factor: 5.464

2.  E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.

Authors:  Xin Tong; Pei Li; Deqiang Zhang; Kyle VanDommelen; Neil Gupta; Liangyou Rui; M Bishr Omary; Lei Yin
Journal:  J Lipid Res       Date:  2016-06-01       Impact factor: 5.922

3.  Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress.

Authors:  Meichan Yang; Deqiang Zhang; Zifeng Zhao; Julian Sit; Mischael Saint-Sume; Omar Shabandri; Kezhong Zhang; Lei Yin; Xin Tong
Journal:  FASEB J       Date:  2020-08-11       Impact factor: 5.191

4.  Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.

Authors:  Veronica Krenn; Camilla Bosone; Thomas R Burkard; Julia Spanier; Ulrich Kalinke; Arianna Calistri; Cristiano Salata; Raissa Rilo Christoff; Patricia Pestana Garcez; Ali Mirazimi; Jürgen A Knoblich
Journal:  Cell Stem Cell       Date:  2021-04-09       Impact factor: 25.269

5.  Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.

Authors:  Kenneth Allen Dyar; Michaël Jean Hubert; Ashfaq Ali Mir; Stefano Ciciliot; Dominik Lutter; Franziska Greulich; Fabiana Quagliarini; Maximilian Kleinert; Katrin Fischer; Thomas Oliver Eichmann; Lauren Emily Wright; Marcia Ivonne Peña Paz; Alberto Casarin; Vanessa Pertegato; Vanina Romanello; Mattia Albiero; Sara Mazzucco; Rosario Rizzuto; Leonardo Salviati; Gianni Biolo; Bert Blaauw; Stefano Schiaffino; N Henriette Uhlenhaut
Journal:  PLoS Biol       Date:  2018-08-10       Impact factor: 8.029

6.  Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.

Authors:  Yonghui Wu; Xinyi Lin; Ives Yubin Lim; Li Chen; Ai Ling Teh; Julia L MacIsaac; Kok Hian Tan; Michael S Kobor; Yap Seng Chong; Peter D Gluckman; Neerja Karnani
Journal:  Clin Epigenetics       Date:  2019-02-11       Impact factor: 6.551

7.  The transcription factor NFIL3 controls regulatory T-cell function and stability.

Authors:  Hyeong Su Kim; Hyogon Sohn; Sung Woong Jang; Gap Ryol Lee
Journal:  Exp Mol Med       Date:  2019-07-16       Impact factor: 8.718

8.  The aberrant expression of rhythm genes affects the genome instability and regulates the cancer immunity in pan-cancer.

Authors:  Jian Zhou; Xinhui Li; Minghui Zhang; Ji'nan Gong; Qi Li; Baocong Shan; Tianzhen Wang; Lei Zhang; Tongsen Zheng; Xiaobo Li
Journal:  Cancer Med       Date:  2020-01-12       Impact factor: 4.452

9.  Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.

Authors:  Emanuel Barth; Akash Srivastava; Diane Wengerodt; Milan Stojiljkovic; Hubertus Axer; Otto W Witte; Alexandra Kretz; Manja Marz
Journal:  Aging (Albany NY)       Date:  2021-12-19       Impact factor: 5.682

10.  Alterations in chromatin accessibility during osteoblast and adipocyte differentiation in human mesenchymal stem cells.

Authors:  Jianyun Liu; Lijun Gan; Baichen Ma; Shan He; Ping Wu; Huiming Li; Jianjun Xiong
Journal:  BMC Med Genomics       Date:  2022-01-31       Impact factor: 3.063
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