| Literature DB >> 26531691 |
Lishomwa C Ndhlovu1,2, Michelle L D'Antoni1,2, Jintanat Ananworanich3,4,5, Mary Margaret Byron1,2, Thep Chalermchai2, Pasiri Sithinamsuwan6, Somporn Tipsuk2, Erika Ho1, Bonnie M Slike4,5, Alexandra Schuetz4,7, Guangxiang Zhang2,8, Melissa Agsalda-Garcia1,2, Bruce Shiramizu1,2, Cecilia M Shikuma1, Victor Valcour9.
Abstract
HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2(+)non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2(+)non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2(+)non-classical monocytes as an independent index of cognitive impairment.Entities:
Keywords: C-C chemokine receptor (CCR) CCR2; CD163; HIV-associated neurocognitive disorders (HAND); Monocytes; Neopterin
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Year: 2015 PMID： 26531691 PMCID： PMC4633708 DOI： 10.1016/j.jneuroim.2015.08.020
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478