Literature DB >> 26530170

The biphasic bioresorbable scaffold (Trufit(®)) in the osteochondral knee lesions: long-term clinical and MRI assessment in 30 patients.

G Dell'Osso1, V Bottai1, G Bugelli1, T Manisco1, N Cazzella1, F Celli1, G Guido1, S Giannotti2.   

Abstract

BACKGROUND: Chondral or osteochondral defects have been reported in 60-67 % of patients in studies reporting knee arthroscopies. The surgical management of chondral and osteochondral defects (OCD's) of the articular surface of the knee joint remains a controversial topic. Osteochondral injuries can be treated with transfer cartilage procedure and with implantation of biodegradable scaffolds. For patients over 50 years old with largest osteochondral lesions, we prefer to use the biodegradable scaffold, like Trufit(®) plug (Smith & Nephew, Andover, MA). The purpose of this study is to evaluate the outcome of this series of surgical procedure with Trufit.
METHODS: In our institute, the Trufit was used for the treatment of one or more focal osteochondral lesions of the femoral condyles positive MRI with or without concomitant ligamentous or meniscal pathology. We reviewed 30 patients with mean age of 60.57 years (range 32-79 years) with a clinical and imaging control at 6, 12, 24 and 48 months of follow-up.
RESULTS: The clinical evaluation has shown the good outcome. The MRI conducted has shown the progressive partial integration of the scaffolds.
CONCLUSIONS: The results obtained indicate a clear improvement of the clinical symptoms and slowing joint degeneration. The clinical and imaging results confirm that the Trufit constitutes a valid surgical alternative in case of focal osteochondral.

Entities:  

Keywords:  Knee; Osteochondral lesions; Scaffold

Mesh:

Year:  2015        PMID: 26530170     DOI: 10.1007/s12306-015-0383-y

Source DB:  PubMed          Journal:  Musculoskelet Surg        ISSN: 2035-5114


  8 in total

1.  TruFit CB bone plug: chondral repair, scaffold design, surgical technique and early experiences.

Authors:  Joel T K Melton; Adrian J Wilson; Phillip Chapman-Sheath; Andrew J Cossey
Journal:  Expert Rev Med Devices       Date:  2010-05       Impact factor: 3.166

2.  A pilot study of the use of an osteochondral scaffold plug for cartilage repair in the knee and how to deal with early clinical failures.

Authors:  Aad A M Dhollander; Koen Liekens; Karl F Almqvist; René Verdonk; Stijn Lambrecht; Dirk Elewaut; Gust Verbruggen; Peter C M Verdonk
Journal:  Arthroscopy       Date:  2011-10-20       Impact factor: 4.772

3.  Delayed incorporation of a TruFit plug: perseverance is recommended.

Authors:  Michael Robert Carmont; Richard Carey-Smith; Adnan Saithna; Manpreet Dhillon; Peter Thompson; Tim Spalding
Journal:  Arthroscopy       Date:  2009-07       Impact factor: 4.772

4.  Techniques for cartilage repair in chondral and osteochondral defects of the knee.

Authors:  Joel Thomas Kirk Melton; Andrew James Cossey
Journal:  Acta Orthop Belg       Date:  2011-04       Impact factor: 0.500

5.  A cell-free scaffold-based cartilage repair provides improved function hyaline-like repair at one year.

Authors:  Alberto Siclari; Gennaro Mascaro; Chiara Gentili; Ranieri Cancedda; Eugenio Boux
Journal:  Clin Orthop Relat Res       Date:  2011-10-01       Impact factor: 4.176

6.  A computed tomography scan assessment of synthetic multiphase polymer scaffolds used for osteochondral defect repair.

Authors:  F Alan Barber; William D Dockery
Journal:  Arthroscopy       Date:  2010-10-16       Impact factor: 4.772

Review 7.  The subchondral bone in articular cartilage repair: current problems in the surgical management.

Authors:  Andreas H Gomoll; Henning Madry; Gunnar Knutsen; Niek van Dijk; Romain Seil; Mats Brittberg; Elizaveta Kon
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2010-02-04       Impact factor: 4.342

Review 8.  Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review.

Authors:  I M Khan; S J Gilbert; S K Singhrao; V C Duance; C W Archer
Journal:  Eur Cell Mater       Date:  2008-09-03       Impact factor: 3.942

  8 in total
  7 in total

1.  Biphasic bioresorbable scaffold (TruFit®) in knee osteochondral defects: 3-T MRI evaluation of osteointegration in patients with a 5-year minimum follow-up.

Authors:  G Bugelli; F Ascione; G Dell'Osso; V Zampa; S Giannotti
Journal:  Musculoskelet Surg       Date:  2017-11-21

2.  LARS™ in ACL reconstruction: evaluation of 60 cases with 5-year minimum follow-up.

Authors:  G Bugelli; G Dell'Osso; F Ascione; E Gori; V Bottai; S Giannotti
Journal:  Musculoskelet Surg       Date:  2017-09-05

3.  Cartilage Restoration of Patellofemoral Lesions: A Systematic Review.

Authors:  Renato Andrade; Joni Nunes; Betina B Hinckel; Jordan Gruskay; Sebastiano Vasta; Ricardo Bastos; J Miguel Oliveira; Rui L Reis; Andreas H Gomoll; João Espregueira-Mendes
Journal:  Cartilage       Date:  2019-12-17       Impact factor: 3.117

Review 4.  Osteochondral tissue engineering: Perspectives for clinical application and preclinical development.

Authors:  Chengchong Ai; Yee Han Dave Lee; Xuan Hao Tan; Si Heng Sharon Tan; James Hoi Po Hui; James Cho-Hong Goh
Journal:  J Orthop Translat       Date:  2021-10-11       Impact factor: 5.191

5.  Synthetic Biphasic Scaffolds versus Microfracture for Articular Cartilage Defects of the Knee: A Retrospective Comparative Study.

Authors:  Dean Wang; Danyal H Nawabi; Aaron J Krych; Kristofer J Jones; Joseph Nguyen; Ameer M Elbuluk; Nadja A Farshad-Amacker; Hollis G Potter; Riley J Williams
Journal:  Cartilage       Date:  2020-02-11       Impact factor: 3.117

Review 6.  Recent Approaches to the Manufacturing of Biomimetic Multi-Phasic Scaffolds for Osteochondral Regeneration.

Authors:  Ryan Longley; Ana Marina Ferreira; Piergiorgio Gentile
Journal:  Int J Mol Sci       Date:  2018-06-13       Impact factor: 5.923

Review 7.  Multi-layer cell-free scaffolds for osteochondral defects of the knee: a systematic review and meta-analysis of clinical evidence.

Authors:  Angelo Boffa; Luca Solaro; Alberto Poggi; Luca Andriolo; Davide Reale; Alessandro Di Martino
Journal:  J Exp Orthop       Date:  2021-07-30
  7 in total

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