Literature DB >> 20420556

TruFit CB bone plug: chondral repair, scaffold design, surgical technique and early experiences.

Joel T K Melton1, Adrian J Wilson, Phillip Chapman-Sheath, Andrew J Cossey.   

Abstract

The TruFit CB osteochondral scaffold plug is a commercially available and licensed scaffold implant for the treatment of chondral and osteochondral defects of the knee. A number of surgical techniques have been described that are designed to achieve neocartilaginous tissue cover of a chondral defect, but many result in fibrocartilage tissue, not type II collagen hyaline cartilage. This fibrocartilage layer can fail with high shear forces in the knee joint, and lead to ongoing articular surface irregularity and subsequent secondary arthritic change. Recent research and clinical interest has focused on employing tissue-engineering techniques utilizing scaffolds in an attempt to obtain cartilage repair tissue that is histologically and biomechanically superior. The TruFit CB implant is one such device. This article describes the techniques of attempted chondral repair and the problems that can be experienced. Current concepts in chondral scaffold design are discussed, and the surgical technique and early experiences with the TruFit CB implant are presented.

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Year:  2010        PMID: 20420556     DOI: 10.1586/erd.10.15

Source DB:  PubMed          Journal:  Expert Rev Med Devices        ISSN: 1743-4440            Impact factor:   3.166


  18 in total

1.  Arthroscopic treatment of osteochondral knee defects with resorbable biphasic synthetic scaffold: clinical and radiological results and long-term survival analysis.

Authors:  Riccardo D'Ambrosi; Francesco Giacco; Vincenza Ragone; Nicola Ursino
Journal:  Int Orthop       Date:  2018-12-11       Impact factor: 3.075

2.  Treatment of focal chondral lesions in the knee using a synthetic scaffold plug: Long-term clinical and radiological results.

Authors:  Faiz S Shivji; Aadil Mumith; Sam Yasen; Joel Tk Melton; Adrian J Wilson
Journal:  J Orthop       Date:  2020-01-14

3.  Biphasic bioresorbable scaffold (TruFit®) in knee osteochondral defects: 3-T MRI evaluation of osteointegration in patients with a 5-year minimum follow-up.

Authors:  G Bugelli; F Ascione; G Dell'Osso; V Zampa; S Giannotti
Journal:  Musculoskelet Surg       Date:  2017-11-21

Review 4.  Challenges in engineering osteochondral tissue grafts with hierarchical structures.

Authors:  Ivana Gadjanski; Gordana Vunjak-Novakovic
Journal:  Expert Opin Biol Ther       Date:  2015-07-20       Impact factor: 4.388

5.  Autologous osteochondral mosaicplasty or TruFit plugs for cartilage repair.

Authors:  Paul Hindle; Jane L Hendry; John F Keating; Leela C Biant
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2013-04-16       Impact factor: 4.342

6.  A one-step treatment for chondral and osteochondral knee defects: clinical results of a biomimetic scaffold implantation at 2 years of follow-up.

Authors:  Elizaveta Kon; Giuseppe Filardo; Francesco Perdisa; Alessandro Di Martino; Maurizio Busacca; Federica Balboni; Andrea Sessa; Maurilio Marcacci
Journal:  J Mater Sci Mater Med       Date:  2014-03-06       Impact factor: 3.896

7.  The biphasic bioresorbable scaffold (Trufit(®)) in the osteochondral knee lesions: long-term clinical and MRI assessment in 30 patients.

Authors:  G Dell'Osso; V Bottai; G Bugelli; T Manisco; N Cazzella; F Celli; G Guido; S Giannotti
Journal:  Musculoskelet Surg       Date:  2015-11-03

8.  Matrix generation within a macroporous non-degradable implant for osteochondral defects is not enhanced with partial enzymatic digestion of the surrounding tissue: evaluation in an in vivo rabbit model.

Authors:  Aaron J Krych; Florian Wanivenhaus; Kenneth W Ng; Stephen Doty; Russell F Warren; Suzanne A Maher
Journal:  J Mater Sci Mater Med       Date:  2013-07-12       Impact factor: 3.896

9.  Autologous Dual-Tissue Transplantation for Osteochondral Repair: Early Clinical and Radiological Results.

Authors:  Bjørn Borsøe Christensen; Casper Bindzus Foldager; Jonas Jensen; Martin Lind
Journal:  Cartilage       Date:  2015-07       Impact factor: 4.634

10.  TruFit Plug for Repair of Osteochondral Defects-Where Is the Evidence? Systematic Review of Literature.

Authors:  J Verhaegen; S Clockaerts; G J V M Van Osch; J Somville; P Verdonk; P Mertens
Journal:  Cartilage       Date:  2015-01       Impact factor: 4.634

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