Literature DB >> 26526786

Opportunity Knocks: Organic Chemistry for Fragment-Based Drug Discovery (FBDD).

Christopher W Murray1, David C Rees2.   

Abstract

Keywords:  biological chemistry; drug design; drug discovery; fragment-based drug discovery

Mesh：

Year:  2015        PMID： 26526786     DOI： 10.1002/anie.201506783

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  32 in total

1.  The influence of hydrogen bonding on partition coefficients.

Authors:  Nádia Melo Borges; Peter W Kenny; Carlos A Montanari; Igor M Prokopczyk; Jean F R Ribeiro; Josmar R Rocha; Geraldo Rodrigues Sartori
Journal:  J Comput Aided Mol Des       Date:  2017-01-04       Impact factor: 3.686

Review 2.  Twenty years on: the impact of fragments on drug discovery.

Authors:  Daniel A Erlanson; Stephen W Fesik; Roderick E Hubbard; Wolfgang Jahnke; Harren Jhoti
Journal:  Nat Rev Drug Discov       Date:  2016-07-15       Impact factor: 84.694

3.  Target-specific NMR detection of protein-ligand interactions with antibody-relayed 15N-group selective STD.

Authors:  Anasztázia Hetényi; Zsófia Hegedűs; Roberta Fajka-Boja; Éva Monostori; Katalin E Kövér; Tamás A Martinek
Journal:  J Biomol NMR       Date:  2016-11-24       Impact factor: 2.835

4.  Transition-Metal-Free C3 Arylation of Indoles with Aryl Halides.

Authors:  Ji Chen; Jimmy Wu
Journal:  Angew Chem Int Ed Engl       Date:  2017-03-03       Impact factor: 15.336

5.  Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis.

Authors:  Maryne A J Dubois; Rosemary A Croft; Yujie Ding; Chulho Choi; Dafydd R Owen; James A Bull; James J Mousseau
Journal:  RSC Med Chem       Date:  2021-10-06

6.  Iridium(I)-Catalyzed α-C(sp3)-H Alkylation of Saturated Azacycles.

Authors:  Pritha Verma; Jeremy M Richter; Nikita Chekshin; Jennifer X Qiao; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2020-03-09       Impact factor: 15.419

7.  Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

Authors:  Sarah L Kidd; Elaine Fowler; Till Reinhardt; Thomas Compton; Natalia Mateu; Hector Newman; Dom Bellini; Romain Talon; Joseph McLoughlin; Tobias Krojer; Anthony Aimon; Anthony Bradley; Michael Fairhead; Paul Brear; Laura Díaz-Sáez; Katherine McAuley; Hannah F Sore; Andrew Madin; Daniel H O'Donovan; Kilian V M Huber; Marko Hyvönen; Frank von Delft; Christopher G Dowson; David R Spring
Journal:  Chem Sci       Date:  2020-05-14       Impact factor: 9.825

Review 8.  Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence.

Authors:  José T Moreira-Filho; Arthur C Silva; Rafael F Dantas; Barbara F Gomes; Lauro R Souza Neto; Jose Brandao-Neto; Raymond J Owens; Nicholas Furnham; Bruno J Neves; Floriano P Silva-Junior; Carolina H Andrade
Journal:  Front Immunol       Date:  2021-05-31       Impact factor: 7.561

Review 9.  Fragment-based drug discovery: opportunities for organic synthesis.

Authors:  Jeffrey D St Denis; Richard J Hall; Christopher W Murray; Tom D Heightman; David C Rees
Journal:  RSC Med Chem       Date:  2020-12-24

10.  Exploring protein hotspots by optimized fragment pharmacophores.

Authors:  Dávid Bajusz; Warren S Wade; Grzegorz Satała; Andrzej J Bojarski; Janez Ilaš; Jessica Ebner; Florian Grebien; Henrietta Papp; Ferenc Jakab; Alice Douangamath; Daren Fearon; Frank von Delft; Marion Schuller; Ivan Ahel; Amanda Wakefield; Sándor Vajda; János Gerencsér; Péter Pallai; György M Keserű
Journal:  Nat Commun       Date:  2021-05-27       Impact factor: 14.919
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