Jeffrey Perl1, Simon J Davies2, Mark Lambie2, Ronald L Pisoni3, Keith McCullough3, David W Johnson4, James A Sloand5, Sarah Prichard5, Hideki Kawanishi6, Francesca Tentori7, Bruce M Robinson8. 1. Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA Division of Nephrology, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada jeff.perl@utoronto.ca. 2. Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University and University Hospitals of North Midlands,Stoke-on-Trent, United Kingdom. 3. Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA. 4. Australasian Kidney Trials Network, School of Medicine, University of Queensland, Brisbane, Australia Princess Alexandra Hospital, Brisbane, Queensland, Australia. 5. Baxter Healthcare, Deerfield, Illiniois, USA. 6. Akane Foundation, Tsuchiya General Hospital, Nakaku, Hiroshima, Japan. 7. Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA Vanderbilt University Medical Center, Nashville, Tennessee, USA. 8. Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Abstract
UNLABELLED: ♦ BACKGROUND: Extending technique survival on peritoneal dialysis (PD) remains a major challenge in optimizing outcomes for PD patients while increasing PD utilization. The primary objective of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is to identify modifiable practices associated with improvements in PD technique and patient survival. In collaboration with the International Society for Peritoneal Dialysis (ISPD), PDOPPS seeks to standardize PD-related data definitions and provide a forum for effective international collaborative clinical research in PD. ♦ METHODS: The PDOPPS is an international prospective cohort study in Australia, Canada, Japan, the United Kingdom (UK), and the United States (US). Each country is enrolling a random sample of incident and prevalent patients from national samples of 20 to 80 sites with at least 20 patients on PD. Enrolled patients will be followed over an initial 3-year study period. Demographic, comorbidity, and treatment-related variables, and patient-reported data, will be collected over the study course. The primary outcome will be all-cause PD technique failure or death; other outcomes will include cause-specific technique failure, hospitalizations, and patient-reported outcomes. ♦ RESULTS: A high proportion of the targeted number of study sites has been recruited to date in each country. Several ancillary studies have been funded with high momentum toward expansion to new countries and additional participation. ♦ CONCLUSION: The PDOPPS is the first large, international study to follow PD patients longitudinally to capture clinical practice. With data collected, the study will serve as an invaluable resource and research platform for the international PD community, and provide a means to understand variation in PD practices and outcomes, to identify optimal practices, and to ultimately improve outcomes for PD patients.
UNLABELLED: ♦ BACKGROUND: Extending technique survival on peritoneal dialysis (PD) remains a major challenge in optimizing outcomes for PDpatients while increasing PD utilization. The primary objective of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is to identify modifiable practices associated with improvements in PD technique and patient survival. In collaboration with the International Society for Peritoneal Dialysis (ISPD), PDOPPS seeks to standardize PD-related data definitions and provide a forum for effective international collaborative clinical research in PD. ♦ METHODS: The PDOPPS is an international prospective cohort study in Australia, Canada, Japan, the United Kingdom (UK), and the United States (US). Each country is enrolling a random sample of incident and prevalent patients from national samples of 20 to 80 sites with at least 20 patients on PD. Enrolled patients will be followed over an initial 3-year study period. Demographic, comorbidity, and treatment-related variables, and patient-reported data, will be collected over the study course. The primary outcome will be all-cause PD technique failure or death; other outcomes will include cause-specific technique failure, hospitalizations, and patient-reported outcomes. ♦ RESULTS: A high proportion of the targeted number of study sites has been recruited to date in each country. Several ancillary studies have been funded with high momentum toward expansion to new countries and additional participation. ♦ CONCLUSION: The PDOPPS is the first large, international study to follow PDpatients longitudinally to capture clinical practice. With data collected, the study will serve as an invaluable resource and research platform for the international PD community, and provide a means to understand variation in PD practices and outcomes, to identify optimal practices, and to ultimately improve outcomes for PDpatients.
Authors: Jeffrey Perl; Ron Wald; Philip McFarlane; Joanne M Bargman; Edward Vonesh; Yingbo Na; S Vanita Jassal; Louise Moist Journal: J Am Soc Nephrol Date: 2011-04-21 Impact factor: 10.121
Authors: Michel Jadoul; Jyothi Thumma; Douglas S Fuller; Francesca Tentori; Yun Li; Hal Morgenstern; David Mendelssohn; Tadashi Tomo; Jean Ethier; Friedrich Port; Bruce M Robinson Journal: Clin J Am Soc Nephrol Date: 2012-03-08 Impact factor: 8.237
Authors: Ronald L Pisoni; Eric W Young; Dawn M Dykstra; Roger N Greenwood; Erwin Hecking; Brenda Gillespie; Robert A Wolfe; David A Goodkin; Philip J Held Journal: Kidney Int Date: 2002-01 Impact factor: 10.612
Authors: Ronald L Pisoni; Brenda W Gillespie; David M Dickinson; Kenneth Chen; Michael H Kutner; Robert A Wolfe Journal: Am J Kidney Dis Date: 2004-11 Impact factor: 8.860
Authors: Htay Htay; Yeoungjee Cho; Elaine M Pascoe; Darsy Darssan; Annie-Claire Nadeau-Fredette; Carmel Hawley; Philip A Clayton; Monique Borlace; Sunil V Badve; Kamal Sud; Neil Boudville; Stephen P McDonald; David W Johnson Journal: Clin J Am Soc Nephrol Date: 2017-06-21 Impact factor: 8.237
Authors: Jenny I Shen; Martin J Schreiber; Junhui Zhao; Bruce M Robinson; Ronald L Pisoni; Rajnish Mehrotra; Matthew J Oliver; Tadashi Tomo; Kriang Tungsanga; Isaac Teitelbaum; Arshia Ghaffari; Mark Lambie; Jeffrey Perl Journal: Clin J Am Soc Nephrol Date: 2019-07-05 Impact factor: 8.237
Authors: Annie-Claire Nadeau-Fredette; David W Johnson; Carmel M Hawley; Elaine M Pascoe; Yeoungjee Cho; Philip A Clayton; Monique Borlace; Sunil V Badve; Kamal Sud; Neil Boudville; Stephen P McDonald Journal: Perit Dial Int Date: 2016-01-13 Impact factor: 1.756
Authors: Neil Boudville; David W Johnson; Junhui Zhao; Brian A Bieber; Ronald L Pisoni; Beth Piraino; Judith Bernardini; Sharon J Nessim; Yasuhiko Ito; Graham Woodrow; Fiona Brown; John Collins; Talerngsak Kanjanabuch; Cheuk-Chun Szeto; Jeffrey Perl Journal: Nephrol Dial Transplant Date: 2019-12-01 Impact factor: 5.992
Authors: Patrick G Lan; Philip A Clayton; David W Johnson; Stephen P McDonald; Monique Borlace; Sunil V Badve; Kamal Sud; Neil Boudville Journal: Perit Dial Int Date: 2016-05-04 Impact factor: 1.756