Literature DB >> 2652391

Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

N Maizels.   

Abstract

Gene conversion has played a major role in molding eukaryotic genomes, and this same mechanism mediates targeted sequence diversification of a variety of genes in response to developmental or environmental stimuli. Here I review data indicating that gene conversion may also be the molecular mechanism of somatic hypermutation at the mammalian immunoglobulin loci.

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Year:  1989        PMID： 2652391     DOI： 10.1016/0168-9525(89)90004-8

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  22 in total

Review 1.  Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.

Authors:  M Diaz; M F Flajnik; N Klinman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

Review 2.  Somatic immunoglobulin hypermutation.

Authors:  Marilyn Diaz; Paolo Casali
Journal:  Curr Opin Immunol       Date:  2002-04       Impact factor: 7.486

3.  Simulation study of a multigene family, with special reference to the evolution of compensatory advantageous mutations.

Authors:  C J Basten; T Ohta
Journal:  Genetics       Date:  1992-09       Impact factor: 4.562

4.  Ectopic recombination within homologous immunoglobulin mu gene constant regions in a mouse hybridoma cell line.

Authors:  M D Baker; L R Read
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

5.  Gene repeat expansion and contraction by spontaneous intrachromosomal homologous recombination in mammalian cells.

Authors:  Leah R Read; Steven J Raynard; Ania Rukść; Mark D Baker
Journal:  Nucleic Acids Res       Date:  2004-02-20       Impact factor: 16.971

6.  Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

Authors:  G W Both; L Taylor; J W Pollard; E J Steele
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

7.  Duplication of the gamma-globin gene mediated by L1 long interspersed repetitive elements in an early ancestor of simian primates.

Authors:  D H Fitch; W J Bailey; D A Tagle; M Goodman; L Sieu; J L Slightom
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

8.  Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.

Authors:  S Kim; E H Humphries; L Tjoelker; L Carlson; C B Thompson
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

9.  Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.

Authors:  M Allegrucci; B A Newman; G O Young-Cooper; C B Alexander; D Meier; A S Kelus; R G Mage
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

10.  Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae.

Authors:  A Datta; A Adjiri; L New; G F Crouse; S Jinks Robertson
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272
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