| Literature DB >> 26507168 |
Guan-Zheng Luo1, Mario Andres Blanco2, Eric Lieberman Greer3, Chuan He1, Yang Shi2.
Abstract
DNA N(6)-adenine methylation (N(6)-methyladenine; 6mA) in prokaryotes functions primarily in the host defence system. The prevalence and significance of this modification in eukaryotes had been unclear until recently. Here, we discuss recent publications documenting the presence of 6mA in Chlamydomonas reinhardtii, Drosophila melanogaster and Caenorhabditis elegans; consider possible roles for this DNA modification in regulating transcription, the activity of transposable elements and transgenerational epigenetic inheritance; and propose 6mA as a new epigenetic mark in eukaryotes.Entities:
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Year: 2015 PMID： 26507168 PMCID： PMC4763336 DOI： 10.1038/nrm4076
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444